血残粒胆固醇水平与冠心病和心肌梗死风险的两样本孟德尔随机化研究  

Association between serum remnant cholesterol level and coronary heart disease and myocardial infarction:a two-sample Mendelian randomization study

作　　者：杜冬杰 陈健 王诗悦 查理[1] 尚容仿 孙冬雪 钟鸣 金恩泽[1] DU Dongjie;CHEN Jian;WANG Shiyue;ZHA Li;SHANG Rongfang;SUN Dongxue;ZHONG Ming;JIN Enze(Department of Cardiology,the Fourth Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150000,China)

机构地区：[1]哈尔滨医科大学附属第四医院心内科,黑龙江省哈尔滨市150000

出　　处：《中国动脉硬化杂志》2023年第6期510-516,共7页Chinese Journal of Arteriosclerosis

摘　　要：[目的]探索血液中残粒胆固醇(RC)水平与冠心病(CHD)和心肌梗死(MI)的因果关系。[方法]采用两样本孟德尔随机化(MR)分析方法研究RC与CHD和MI的潜在因果关系。使用随机效应逆方差加权(IVW)法作为两样本MR分析的主要分析方法,并采用敏感性分析(包括异质性检验、多效性分析和逐个剔除检验)评估MR分析结果的稳健性。[结果]IVW法分析结果显示,RC与CHD和MI发生风险之间的关联具有统计学意义(CHD:OR=1.57,95%CI:1.40~1.76,P=2.01E-14;MI:OR=1.59,95%CI:1.40~1.79,P=1.26E-13)。MR-Egger回归结果提示筛选出的单核苷酸多态性(SNP)与CHD和MI不存在基因多效性(分别为P=0.9241、P=0.7405)。[结论]血液中RC水平升高与CHD和MI风险增加存在因果关系。Aim To investigate the association between serum remnant cholesterol(RC)level and coronary heart disease(CHD)and myocardial infarction(MI).Methods Two-sample Mendelian randomization(MR)analysis was used to investigate the potential causal association between RC and CHD,MI.The inverse variance weighted(IVW)model was used as the main analytical method for the two-sample MR analysis and was followed by sensitivity analysis,including heterogeneity test,horizontal pleiotropy test,and leave-one-out analysis,to evaluate the robustness of the MR results.Results The IVW method showed statistically significant associations between RC and increased risk of CHD and MI(CHD:OR=1.57,95%CI:1.40~1.76,P=2.01 E-14;MI:OR=1.59,95%CI:1.40~1.79,P=1.26E-13).MR-Egger regression results suggested that the screened single nucleotide polymorphisms(SNP)were not genetically pleiotropic with CHD and MI(The P values for CHD and MI were P=0.9241 and P=0.7405,respectively).Conclusion Elevated serum remnant cholesterol level is causally associated with an increased risk of CHD and MI.

关 键 词：残粒胆固醇 冠心病 心肌梗死 孟德尔随机化 

分 类 号：R5[医药卫生—内科学]