lncRNA减轻心肌缺血再灌注损伤的研究进展  

Developments in lncRNA reducing myocardial ischemia/reperfusion injury

作　　者：成姣 谢佳欣 刘晨 黄骥 韦星[1] CHENG Jiao;XIE Jiaxin;LIU Chen;HUANG Ji;WEI Xing(Institute of Cardiovascular Diseases,University of South China&Key Laboratory for Arteriosclerology of Hunan Province&International Scientific and Technological Innovation Cooperation Base for Arteriosclerotic Diseases in Hunan Province,Hengyang,Hunan 421001,China)

机构地区：[1]南华大学心血管疾病研究所、动脉硬化学湖南省重点实验室、湖南省动脉硬化性疾病国际科技创新合作基地,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2023年第6期539-545,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(82100789);湖南省教育厅科学研究重点项目(19A432)。

摘　　要：长链非编码RNA(lncRNA)是一类长度大于200个核苷酸且无蛋白质编码能力的RNA,但在增殖、凋亡、迁移、侵袭和分化等多种生物过程中起着非常重要的调节作用。研究发现lncRNA与心肌缺血再灌注(I/R)损伤的发生发展密切相关。本综述讨论了lncRNA减少心肌I/R损伤及其可能机制的研究进展。Long non-coding RNA(lncRNA)is a class of RNA more than 200 nucleotides long and has no protein-coding capacity,but it plays a very important role in regulating various biological processes such as proliferation,apoptosis,migration,invasion and differentiation.It has found that lncRNA is closely related to the development of myocardial ischemia/reperfusion(I/R)injury.This review discusses the advances in the reduction of myocardial I/R injury and its possible mechanisms by lncRNA.

关 键 词：长链非编码RNA 心肌缺血再灌注损伤 氧化应激 自噬 炎症反应 细胞凋亡 

分 类 号：R5[医药卫生—内科学] R363[医药卫生—临床医学]