基于因子分析和聚类分析的酒精性肝硬化中医证型研究  

Study on TCM Syndrome Types of Alcoholic Cirrhosis Based on Factor Analysis and Clustering Analysis

作　　者：李冰倩 刘江凯[2] 张雅儒 张建文 LI Bingqian;LIU Jiangkai;ZHANG Yaru;ZHANG Jianwen(The First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450000,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一临床医学院,河南郑州450000 [2]河南中医药大学第一附属医院,河南郑州450000

出　　处：《中国中医药信息杂志》2023年第6期158-163,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：河南省中医管理局国家中医临床研究基地科研专项(2021JDZY003);河南省中医药拔尖人才(2021年)。

摘　　要：目的探索酒精性肝硬化(AC)中医证型分布规律。方法采用回顾性研究方法,收集整理323例AC患者中医四诊信息,进行描述性统计。运用因子分析和聚类分析结合的方法提取27项主要证候条目并进行非线性降维研究。结果通过因子分析提取11个公因子,结合中医证素辨证结果、专业知识和临床实践归为4种证型,依次为脾虚湿盛兼瘀热证108例(33.44%)、肝郁脾虚兼血瘀证86例(26.62%)、脾肾阳虚证70例(21.67%)、肝胆湿热兼血瘀证59例(18.27%)。肝功能Child-Pugh A级以脾虚湿盛兼瘀热证居多,肝功能Child-Pugh B级以脾虚湿盛兼瘀热证和肝郁脾虚兼血瘀证为主,肝功能Child-Pugh C级以肝郁脾虚兼血瘀证和脾肾阳虚证为主。结论AC基本中医证型为脾虚湿盛兼瘀热证、肝郁脾虚兼血瘀证、脾肾阳虚证、肝胆湿热兼血瘀证,肝功能Child-Pugh分级不同的患者中医证型分布规律亦不同。Objective To explore the distribution law of TCM syndrome types in alcoholic cirrhosis(AC).Methods A retrospective study method was used to collect and sort out the information of the TCM four diagnostic methods in 323 AC patients,and descriptive statistics were carried out.A combination of factor analysis and clustering analysis was used to extract 27 main syndrome items and conduct nonlinear dimensionality reduction research.Results Totally 11 common factors were extracted by factor analysis,and combined with the results of TCM syndrome differentiation,professional knowledge and clinical practice,they were classified into 4 syndrome types,including 108 cases(33.44%)of spleen deficiency and excess dampness with heat stasis syndrome,86 cases(26.62%)of liver stagnation and spleen deficiency with blood stasis syndrome,70 cases(21.67%)of spleen-kidney yang deficiency syndrome,and 59 cases(18.27%)of liver and gallbladder damp-heat with blood stasis syndrome.Liver function Child-Pugh grade A was mainly characterized by spleen deficiency and excess dampness with heat stasis syndrome.Liver function Child-Pugh grade B was mainly characterized by spleen deficiency and excess dampness with heat stasis syndrome and liver stagnation and spleen deficiency with blood stasis syndrome.Liver function Child-Pugh grade C was mainly characterized by liver stagnation and spleen deficiency with blood stasis syndrome and spleen-kidney yang deficiency syndrome.Conclusion The basic TCM syndromes of AC are spleen deficiency and excess dampness with heat stasis syndrome,liver stagnation and spleen deficiency with blood stasis syndrome,spleen-kidney yang deficiency syndrome,liver and gallbladder damp-heat with blood stasis syndrome.The distribution law of TCM syndrome types is different in patients with different liver function Child-Pugh grade.

关 键 词：酒精性肝硬化 中医证型 因子分析 聚类分析 

分 类 号：R259.752[医药卫生—中西医结合]