正电子发射断层扫描-直线加速器在生物引导放疗中的应用  

Application of PET-LINAC in Biology-guided Radiotherapy

作　　者：杨欣[1] 赵维 田新智 蔡俊 谢思维 刘琦 彭浩 彭旗宇[6] YANG Xin;ZHAO Wei;TIAN Xinzhi;CAI Jun;XIE Siwei;LIU Qi;PENG Hao;PENG Qiyu(Department of Oncology,The Second Xiangya Hospital of Central South University,Changsha,410011;School of Physics,Beihang University,Beijing,102206;Hangzhou Innovation Institute,Beihang University,Hangzhou,310051;X-Precise(Beijing)Medical Technology Co.Ltd.,Beijing,100176;Suzhou magAssist Medical Technology Co.Ltd.,Suzhou,215000;Institute of Biomedical Engineering,Shenzhen Bay Laboratory,Shenzhen,518067;Department of Medical Physics,Wuhan University,Wuhan,430072)

机构地区：[1]中南大学湘雅二医院肿瘤中心,长沙市410011 [2]北京航空航天大学物理学院,北京市102206 [3]北京航空航天大学杭州创新研究院,杭州市310051 [4]智维精准(北京)医疗科技有限公司,北京市100176 [5]苏州心擎医疗技术有限公司,苏州市215000 [6]深圳湾实验室生物医学工程研究所,深圳市518067 [7]武汉大学医学物理研究中心,武汉市430072

出　　处：《中国医疗器械杂志》2023年第3期237-241,共5页Chinese Journal of Medical Instrumentation

摘　　要：生物引导放疗(biology-guided radiotherapy, BgRT)是一种将PET-CT与直线加速器(LINAC)相结合的外照射放疗方式。BgRT通过PET示踪剂,利用从肿瘤组织处发射出的PET信号进行实时追踪,引导LINAC的治疗束对肿瘤靶区实现定位和照射。相比于传统的LINAC系统,BgRT系统的硬件设计、软件算法、系统整合和使用流程等诸多方面都更为复杂。RefleXion Medical公司研制出了全球首台BgRT系统,但该系统主推的Bg RT核心功能尚处于研发阶段。该研究对Bg RT的技术优势和潜在挑战等方面进行了探讨和展望。Biology-guided radiotherapy(BgRT)is a novel technique of external beam radiotherapy,combining positron emission tomography-computed tomography(PET-CT)with a linear accelerator(LINAC).The key innovation is to utilize PET signals from tracers in tumor tissues for real-time tracking and guiding beamlets.Compared with a traditional LINAC system,a BgRT system is more complex in hardware design,software algorithm,system integration and clinical workflow.RefleXion Medical has developed the world's first BgRT system.Nevertheless,its actively advertised function,PET-guided radiotherapy,is still in the research and development phase.In this review study,we presented a number of issues related to BgRT,including its technical advantages and potential challenges.

关 键 词：正电子断层扫描 直线加速器 生物引导放疗 

分 类 号：R318.6[医药卫生—生物医学工程] TH774[医药卫生—基础医学]