纳米低温生物医学研究进展  

Research Progress of Nano Cryobiomedicine

作　　者：杨帆[1,2,3] 李晓莹 饶伟 YANG Fan;LI Xiaoying;RAO Wei(Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China;School of Future Technology,University of Chinese Academy of Sciences,Beijing 101408,China;Beijing Key Laboratory of Cryo-Biomedical Engineering,Technical Institute of Physics and Chemistry,Beijing 100190,China)

机构地区：[1]中国科学院理化技术研究所,北京100190 [2]中国科学院大学未来技术学院,北京101408 [3]低温生物医学工程学北京市重点实验室,北京100190

出　　处：《真空科学与技术学报》2023年第6期461-480,共20页Chinese Journal of Vacuum Science and Technology

摘　　要：低温生物医学是一个多学科交叉的领域,低温治疗和低温保存作为其主要的应用方向,在重大疾病治疗、延长生物样本保存时间等领域发挥了积极作用。然而传统的低温治疗在实现精准化适形化治疗方面有待突破,低温保存同样面临着大尺度生物样本无法长期低温保存的挑战。纳米材料与技术的引入极大地拓展了低温治疗与低温保存的研究思路,成为克服低温生物医学发展瓶颈的关键因素之一。本文阐述了纳米技术与低温生物医学结合的基本理念及作用机理,归纳总结了几类典型的纳米低温生物医学材料及技术,介绍了纳米材料在冰晶调控、物质递送、强化传热等方面的作用。Cryogenic biomedicine is a multidisciplinary field.As the main application directions,cryosurgery and cryopreservation have played an active role in disease treatment and prolonging the preservation time of biological samples.However,traditional cryotherapy needs to make breakthroughs in achieving intensive killing and satisfying conformal treatment.Cryopreservation also faces the challenges of protective agent loading,ice crystal regulation and rapid rewarming of vitrified samples.The introduction of nanotechnology has greatly expanded the method of cryotherapy and cryopreservation,and has become the key factor to break the bottleneck of cryogenic biomedicine.In this paper,the mechanism of nanotechnology is reviewed,and the applications of nanomaterials in ice regulation,protective agent delivery and heat transfer enhancement are introduced.It is expected to summarize the existing experience and promote faster and better development of the field.

关 键 词：低温治疗 低温保存 纳米材料 纳米技术 

分 类 号：R318.52[医药卫生—生物医学工程]