不同免疫功能检测在梅毒患者诊断中的价值分析  

Value of immune detection in different syphilis patients

作　　者：冉晓丹[1] RAN Xiao-dan(Henan Provincal Hospital of TCM(the Second Affiliated Hospital of Henan TCM University),Zhengzhou 450000,China)

机构地区：[1]河南省中医院(河南省中医药大学第二附属医院),郑州450000

出　　处：《医药论坛杂志》2023年第6期110-112,F0003,共4页Journal of Medical Forum

摘　　要：目的 探讨不同免疫功能检测在梅毒患者诊断中的价值分析。方法 选取驻河南省中医院在2020年1月份到2021年12月份收治的50例梅毒患者为研究对象,其中一期梅毒患者11例,二期梅毒患者20例、潜伏梅毒患者19例。同期选择50例健康体检者为对照组。两组受检者均接受体液免疫检测、细胞免疫检测。对比两组受检者的体液免疫检测、细胞免疫检测结果。结果 梅毒组的IgG、IgA、IgM水平均比对照组高,差异有统计学意义(P<0.05)。一期梅毒患者IgG、IgA、IgM与对照组差异不明显,无统计学意义(P>0.05);二期梅毒患者、潜伏期梅毒患者IgG、IgA、IgM均比对照组高,其中二期梅毒变化最为明显,有统计学意义(P<0.05)。梅毒组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、NK均低于对照组,CD8^(+)高于对照组,有统计学意义(P<0.05)。一期梅毒患者、二期梅毒患者、潜伏期梅毒患者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、NK均比对照组低,CD8^(+)均比对照组高,其中二期梅毒变化最为明显,有统计学意义(P<0.05)。结论 梅毒患者体液免疫功能存在明显亢进,细胞免疫功能存在缺陷,整体表现为自身免疫功能紊乱,临床开展体液免疫、细胞免疫检测,对梅毒患者临床诊断有显著价值。Objective To explore the value of different immune function tests in the diagnosis of syphilis.Methods Totally 50 patients with syphilis treated in our hospital from January 2020 to December 2021 were selected as the research object,including 11 patients with primary syphilis,20 patients with secondary syphilis and 19 patients with latent syphilis.In the same period,50 healthy persons were selected as the control group.Both groups were tested for humoral immunity and cellular immunity.The results of humoral immunity and cellular immunity were compared between the two groups.Results The levels of IgG,IgA and IgM in syphilis group were higher than those in control group(P<0.05).There was no significant difference in IgG,IgA and IgM between the patients with primary syphilis and the control group(P>0.05);IgG,IgA and IgM in patients with secondary syphilis and patients with latent syphilis were higher than those in the control group,and the change of secondary syphilis was the most obvious,which was statistically significant(P<0.05).CD3^(+),CD4^(+),CD4^(+)/CD8^(+) and NK in syphilis group were lower than those in control group,and CD8^(+) was higher than that in control group(P<0.05).CD3^(+),CD4^(+),CD4^(+)/CD8^(+) and NK in patients with primary syphilis,secondary syphilis and latent syphilis were lower than those in the control group,and CD8^(+) was higher than those in the control group.The change of secondary syphilis was the most obvious and statistically significant(P<0.05).Conclusion The humoral immune function of syphilis patients is obviously hyperfunctional,and the cellular immune function is defective.The overall performance is the disorder of autoimmune function.The detection of humoral immunity and cellular immunity is of great value for the clinical diagnosis of syphilis patients.

关 键 词：体液免疫检测 细胞免疫检测 梅毒 梅毒分期 诊断 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]