妇科门诊就诊者HPV感染危险因素分析及HPV疫苗认知情况调查  

Analysis of risk factors of HPV infection and investigation of HPV vaccine cognition in gynecologic outpatients

作　　者：孙红丽 赵子昳 乔菲 位路其 张锦聪 齐卫 冯春蝶[2] SUN Hong-li;ZHAO Zi-yi;QIAO Fei;LU qi;ZHANG Jin-cong;QI Wei;FENG Chun-die(Department of obstetrics and Gynecology,Luohe Hospital of Traditional Chinese Medicine,Luohe,Henan 462000,China;Department of obstetrics department,Luohe Central Hospital,Luohe,Henan 462000,China)

机构地区：[1]漯河市中医院妇产科,河南漯河462000 [2]漯河市中心医院产科,河南漯河462000

出　　处：《医药论坛杂志》2023年第7期54-57,61,共5页Journal of Medical Forum

摘　　要：目的 分析女性子宫颈人乳头瘤病毒(HPV)感染情况及危险因素,调查其对相关疫苗认知情况。方法 选择漯河市中医院2016年12月至2021年12月妇科门诊自愿接受HPV筛查的2 152例女性,比较HPV阳性感染亚型和感染情况分布,分析HPV感染相关危险因素,调查其对相关疫苗认知情况。结果 入组女性HPV高危型主要为HPV16、HPV58和HPV52,低危型主要为HPV11、HPV6,中国人群常见亚型主要为HPVCP8304、HPV53、HPV66。受检女性HPV总感染率为20.77%,其中单一感染16.31%,高于多重感染4.46%;感染类型由高到低依次为高危亚型、低危亚型和混合感染。女性HPV感染与宫颈癌家族史、初婚年龄≤20岁、流产次数>3次和性伴侣个数≥2个有关。阳性者HPV危害性知识知晓率、HPV预防性疫苗知晓率和HPV疫苗接种意愿均低于阴性者。结论 宫颈癌家族史、初婚年龄≤20岁、流产次数>3次和性伴侣个数≥2个是女性HPV感染的危险因素,应加强对HPV相关知识及疫苗普及,降低宫颈癌发生。Objective To analyze the status and risk factors of female cervical human papillomavirus(HPV) infection,and to investigate the knowledge of HPV vaccine.Methods A total of 2152 women who voluntarily underwent HPV screening in the gynecological outpatient department of Luohe Central Hospital from December 2016 to December 2021 were selected to compare the HPV positive infection subtypes and the distribution of infection,analyze the risk factors related to HPV infection,and investigate their cognition of related vaccines.Results The high-risk types of female HPV were mainly HPV16,HPV58 and HPV52,the low-risk types were mainly HPV11 and HPV6,and the common subtypes in Chinese population were mainly HPVCP8304,HPV53 and HPV66.The total infection rate of HPV was 20.77%,and the single infection was 16.31%,which was higher than that of multiple infection 4.46%.The infection types were high-risk subtype,low-risk subtype and mixed infection in descending order.HPV infection in women was associated with a family history of cervical cancer,age at first marriage ≤20 years,number of miscarriages >3,and number of sexual partners ≥2.The rate of knowledge about the harmfulness of HPV,the rate of awareness of HPV preventive vaccine and the willingness to vaccinate HPV in positive subjects were lower than that of negative subjects.Conclusion Family history of cervical cancer,age of first marriage ≤20 years,number of abortion >3 and number of sexual partners ≥2 are risk factors for female HPV infection.HPV related knowledge and vaccine popularization should be strengthened to reduce the incidence of cervical cancer.

关 键 词：人乳头瘤病毒 基因分型 危险因素 知晓率 调查 

分 类 号：R172[医药卫生—妇幼卫生保健]