青蒿琥酯的抗炎作用及机制研究进展  

Anti-inflammatory Effect and Mechanism of Artesunate:A Review

作　　者：李林林 张会敏[2] 宋健[1] 张萧 隋在云[2] 冯玉[1] LI Linlin;ZHANG Huimin;SONG Jian;ZHANG Xiao;SUI Zaiyun;FENG Yu(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong Academy of Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学,济南250355 [2]山东省中医药研究院,济南250014

出　　处：《中国实验方剂学杂志》2023年第12期241-247,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82004037);山东省中医药科技发展项目(M-2022173);齐鲁医派中医学术流派传承项目。

摘　　要：炎症是许多疾病的基础病理过程,可以发生在身体的各个组织和器官,包括癌症在内的多种疾病都是由炎症引起的。迄今虽已有上千种抗炎药物上市,但是这些药物多具有胃肠道损伤的不良反应,甚至还会对机体造成更大的损伤。近年来,中药老药新用的研究方兴未艾,对抗疟特效药青蒿素的创新研究受到国内外学者的广泛关注。青蒿琥酯是青蒿素水溶性较好的衍生物,具有速效、低毒等特点。除对疟疾有显著的治疗作用外,青蒿琥酯还具有潜在的抗炎作用。该综述通过查阅相关文献,详尽地阐述了青蒿琥酯的抗炎作用及机制,发现青蒿琥酯在呼吸系统、肝损伤、骨关节炎、皮炎、肾脏炎症、结肠炎、神经炎症、甚至在新型冠状病毒肺炎(COVID-19)等方面都有良好的抗炎效果;并归纳出青蒿琥酯主要通过作用于核转录因子-κB(NF-κB)、核因子E2相关因子(Nrf2)、磷脂酰激醇3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)、Toll样受体4(TLR4)/髓样分化因子88(MyD88)/肿瘤坏死因子受体相关分子6(TRAF6)、高迁移率族蛋白B1(HMGB1)/晚期糖基化终产物(RAGE)等信号通路,参与凋亡信号转导、介导免疫调节、改善氧化应激等方式来发挥抗炎作用。通过对青蒿琥酯的抗炎作用及机制进行综述,以期为青蒿琥酯在抗炎方面的应用提供参考,为将来青蒿琥酯的进一步开发利用提供借鉴。Inflammation,the basic pathological process of many diseases,can occur in various tissues and organs of the body and cause many diseases including cancer.So far,there are thousands of anti-inflammatory drugs on the market,but most of these drugs have adverse reactions of gastrointestinal injury,and can even cause greater damage to the body.In recent years,the research on the repurpose of Chinese medicine is in the ascendant,and the innovative research on the specific antimalarial drug artemisinin has attracted extensive attention from scholars in China and abroad.Artesunate is a water-soluble derivative of artemisinin,which has the characteristics of quick effect and low toxicity.In addition to its significant therapeutic effect on malaria,artesunate also has a potential anti-inflammatory effect.In this review,the antiinflammatory effect and mechanism of artesunate were elaborated in detail by consulting the relevant literature.It was found that artesunate had good anti-inflammatory effects in the respiratory system,liver injury,osteoarthritis,dermatitis,kidney inflammation,colitis,neuroinflammation,and even in novel coronavirus disease 2019(COVID-19).It was concluded that artesunate mainly participated in apoptotic signal transduction,mediated immune regulation,and improved oxidative stress to play an anti-inflammatory role by acting on nuclear factor-κB(NF-κB),nuclear factor E_2-related factor 2(Nrf2),phosphatidylinositol-3 kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR),Toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)/tumor necrosis factor receptor-associated factor 6(TRAF6),high mobility group box 1(HMGB1)/receptor for advanced glycation endproduct(RAGE),and other pathways.Through the review of the anti-inflammatory effect and mechanism of artesunate,it is expected to provide a reference for the application of artesunate in inflammation resistance and further development and utilization of artesunate in the future.

关 键 词：青蒿琥酯 抗炎作用 机制 研究进展 

分 类 号：R2-0[医药卫生—中医学] R22R285.5R284R33