中医药治疗慢性肾脏疾病矿物质和骨代谢异常相关信号通路研究进展  

Traditional Chinese Medicine Intervenes in Signaling Pathways Associated with CKD-MBD:A Review

作　　者：郭星云 张宁[1] 柳诗意[1] GUO Xingyun;ZHANG Ning;LIU Shiyi(Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing 100102,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院望京医院,北京100102 [2]北京中医药大学,北京100029

出　　处：《中国实验方剂学杂志》2023年第12期248-256,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：中国中医科学院科技创新工程重大攻关项目(C12021A01609);国家自然科学基金青年基金项目(81904156);中央级公益性科研院所基本科研业务费专项(ZZ14-YQ-021)。

摘　　要：中医药在治疗慢性肾脏病矿物质和骨代谢异常(CKD-MBD)具有一定优势,近年来出现许多中药复方及中药单体治疗CKD-MBD的研究。通过文献检索发现,中药治疗CKD-MBD相关通路的机制研究中,以中药自拟复方研究为主,作用途径涉及纤维细胞生长因23/Klotho(FGF23/Klotho)信号通路、Wnt/β-连环蛋白(Wnt/β-catenin)信号通路、核转录因子-κB受体活化因子/核转录因子-κB受体活化因子配体/骨保护素(RANK/RANKL/OPG)系统等多条信号通路,中药能通过调节此系列信号通路改善钙磷代谢、骨代谢紊乱、调控炎症反应、氧化应激、细胞凋亡和自噬,从而治疗CKD-MBD。该文将对这些信号通路和中药治疗CKD-MBD在作用机制领域取得的研究成果进行介绍,以期为中药治疗CKD-MBD的相关研究提供思路和参考。Traditional Chinese medicine(TCM) has certain advantages in the treatment of chronic kidney disease-mineral and bone disorder(CKD-MBD).In recent years,there have been many studies on the treatment of CKD-MBD by Chinese medicinal compounds and monomers.As revealed by literature retrieval,the research on the mechanism of Chinese medicine in intervening in signaling pathways related to CKD-MBD was mainly based on self-made Chinese medicinal compounds,and the action pathways involved fibroblast growth factor 23/Klotho(FGF23/Klotho) signaling pathway,Wnt/β-catenin signaling pathway,receptor activator of nuclear factor-κB/receptor activator of nuclear factor-κB ligand/osteoprotegerin(RANK/RANKL/OPG) system,and other signaling pathways.TCM can improve calcium and phosphorus metabolism and bone metabolism disorder,and regulate inflammatory reaction,oxidative stress,apoptosis,and autophagy by regulating this series of signaling pathways for the treatment of CKD-MBD.This paper introduced the research results of these signaling pathways and the mechanism of TCM in the treatment of CKD-MBD in order to provide ideas and references for the related research of Chinese medicine in the treatment of CKD-MBD.

关 键 词：慢性肾脏病矿物质和骨代谢异常(CKD-MBD) 血管钙化 纤维细胞生长因23/Klotho(FGF23/Klotho)信号通路 Wnt/β-连环蛋白(Wnt/β-catenin)信号通路 核转录因子-κB受体活化因子配体/核转录因子-κB受体活化因子/骨保护素(RANK/RANKL/OPG)信号通路 中医 中药 

分 类 号：R2-0[医药卫生—中医学] R22R285.5R284R2-031R586