基于数据挖掘的中医药辅助治疗老年消化性溃疡的用药规律  

Medication Rules of Traditional Chinese Medicine in Assisted Treatment of Senile Peptic Ulcer Based on Data Mining

作　　者：周嘉培 王小婵 李浩然 王永森[3] 曹志群[3] ZHOU Jiapei;WANG Xiaochan;LI Haoran;WANG Yongsen;CAO Zhiqun(School of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Ji′nan 250355,China;The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Ji′nan 250001,China;Department of Digestive Endoscopy,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Ji′nan 250014,China)

机构地区：[1]山东中医药大学中医学院,济南250355 [2]山东中医药大学第二附属医院,济南250001 [3]山东中医药大学附属医院消化内镜诊疗科,济南250014

出　　处：《世界中医药》2023年第10期1442-1446,共5页World Chinese Medicine

基　　金：山东省自然科学基金项目(ZR2020MH355);山东中医药大学首批科研创新团队项目(220316);2019—2020年度山东省中医药科技发展计划项目(2019—0186);国家重点实验室开放课题(SKL-BMSG2022-02)。

摘　　要：目的:对中医药复方辅助治疗老年消化性溃疡的用药进行统计并进行规律分析。方法:基于国家知识基础设施数据库(CNKI)、中国生物医学文献数据库(CBM)、中国学术期刊数据库(CSPD)及中文科技期刊数据库(CCD)等数据平台,挖掘并筛选相关中药复方,运用Excel进行高频药物统计分析,应用SPSS Modeler 18.0 Apriori算法进行药物间关联规则构建,并联合Cytoscape软件实现共现网络可视化展示。运用SPSS Statistics 26.0进行新方聚类并绘制谱系统,预测药物配伍。结果:经筛选后纳入处方80首,涉及中药112味,用药总频次833次。其中用药频次≥15次的核心药物18味,以补气药所用最广,性味归经以甘、温、脾经为最。关联规则得到常用药物配伍4类共12组。聚类分析以欧式平方距离23为标准,得到具有潜在配伍关系的新方3个。结论:中药复方用药以健脾益气固其本,行气活血治其标,清热燥湿以解毒祛邪,配合收敛止血之药以促进创面愈合,防止出血。用药寒热平调,甘苦合用,辛散酸收,肝肺同治,补泻兼顾,开合有度。Objective:To statistically analyze the medication laws of traditional Chinese medicine(TCM)compound prescriptions in assisted treatment of senile peptic ulcer.Methods:Based on various data platforms such as the CNKI,CBM,CSPD,and CCD,related TCM compound prescriptions were screened and selected.Excel was used for statistical analysis of high-frequency drugs,and SPSS Modeler 18.0 Apriori algorithm was used to construct drug association rules.The co-occurrence network was visualized using Cytoscape software.SPSS Statistics 26.0 was used to cluster new prescriptions and draw spectrum systems to predict drug compatibility.Results:After screening,80 prescriptions involving 112 drugs and a total frequency of 833 times were included.Among them,18 core drugs with a drug frequency≥15 times were used most extensively for tonifying qi,and they were sweet and warm,mainly acting on the spleen meridian.The association rules identified 12 groups of commonly used drug combinations in four categories.Cluster analysis using a standard of Euclidean square distance 23 identified three new prescriptions with potential compatibility relationships.Conclusion:TCM compound prescriptions mainly focus on strengthening the spleen and supplementing qi for consolidating the root,regulating qi and activating blood for treating the manifestations,clearing heat and resolving dampness for removing toxins and expelling pathogenic factors,and promoting wound healing and preventing bleeding.In drug selection,combined use of cold and warm drugs,and bitter and sweet drugs is highlighted.Pungent drugs are used for dispersing and sour drugs for astringing to treat both the liver and lungs.Reinforcement and reduction are both emphasized.

关 键 词：数据挖掘 老年 消化性溃疡 中医药 用药规律 关联规则 聚类分析 配伍应用 

分 类 号：R285[医药卫生—中药学] R259[医药卫生—中医学]