不同商品规格等级党参药材的质量分析  

Quality analysis of Codonopsis pilosula with different commodity specification grades

作　　者：张小慧[1] 仝立国[1] 王亦冰 李志强[3] 席啸虎[3] 王爽 王世伟[3] ZHANG Xiaohui;TONG Liguo;WANG Yibing;LI Zhiqiang;XI Xiaohu;WANG Shuang;WANG Shiwei(Central Laboratory,Shanxi Academy of Traditional Chinese Medicine,Taiyuan 030012,China;Dept.of Pharmacy,Changzhi Medical College,Shanxi Changzhi 046013,China;Dept.of Pharmacy,Shanxi Hospital of Traditional Chinese Medicine,Taiyuan 030012,China)

机构地区：[1]山西省中医药研究院中心实验室,太原030012 [2]长治医学院药学系,山西长治046013 [3]山西省中医院药剂科,太原030012

出　　处：《中国药房》2023年第11期1363-1367,共5页China Pharmacy

基　　金：山西省卫生健康委科研课题(No.2018085);山西省卫生健康委员会“四个一批”科技兴医创新计划项目(No.2020SYS06)。

摘　　要：目的研究不同商品规格等级党参药材的质量,为该药材的市场流通、科研及临床使用提供依据。方法根据目前党参药材的商品规格等级划分标准,收集不同产地、基原、商品规格等级的党参药材共17批,采用高效液相色谱法测定党参苷Ⅰ、党参炔苷和白术内酯Ⅲ的含量,采用《中国药典》(四部)中醇溶性浸出物测定法(通则2201)项下“热浸法”测定其醇溶性浸出物的含量,采用苯酚硫酸法测定其多糖的含量(以D-无水葡萄糖计)。结果对于党参的栽培品种,4种规格3个商品等级的党参药材均含有党参苷Ⅰ和党参炔苷,潞党参、纹党参还含有白术内酯Ⅲ。党参苷Ⅰ、党参炔苷、白术内酯Ⅲ含量方面,栽培药材二等品与一等品含量相当,甚至优于一等品,三等品含量低于一等品、二等品;两种野生党参中党参苷Ⅰ含量最高。醇溶性浸出物和多糖含量方面,栽培药材一等品含量高于二等品,二等品含量高于三等品,野生党参含量较低。结论不同商品规格等级的党参药材栽培品种的内在质量和目前依据性状和基原的规格等级划分标准基本一致,一等药材与二等药材均有较高的指标成分含量,属优质药材。OBJECTIVE To study the quality of Codonopsis pilosula with different commodity specification grades,and to provide the data support for market transactions,scientific research and clinical use.METHODS According to the classification standard of commodity specification grades of C.pilosula,17 batches of C.pilosula from different producing areas,origins and commodity specification grades were collected.The contents of tangshenoside Ⅰ,lobetyolin and atractylenolide Ⅲ were determined by HPLC.The contents of alcohol-soluble extracts were determined by hot dipping method stated in general rule 2201 of Chinese Pharmacopeia(part Ⅳ).The contents of polysaccharide were determined by phenol-sulfuric acid method(calculated by D-glucose anhydrous).RESULTS For cultivar of C.pilosula,four specifications and three commodity grades of C.pilosula all contained tangshenosideⅠand lobetyolin;Radix C.pilosula from Shanxi of China and C.pilosula from Wenxian County of China,also contained atractylenolide Ⅲ.In terms of the contents of tangshenosideⅠ,lobetyolin and atractylenolide Ⅲ,the content of second class was equivalent to that of first class,even better than the first class,while the content of third class was lower than that of first class and second class;the content of tangshenosideⅠwas the highest among the two types of wild C.pilosula.The contents of alcohol-soluble extracts and polysaccharides in first class cultivated C.pilosula were higher than those of second class,and the second class was higher than the third class;wild C.pilosula had low content of alcohol-soluble extracts and polysaccharides.CONCLUSIONS The internal quality of C.pilosula is basically consistent with the classification standard of different commodity specification grades;the content of each indicator in first-class and second-class medicinal herb is high,making them high-quality medicinal herbs.

关 键 词：党参 商品规格等级 党参苷Ⅰ 党参炔苷 白术内酯Ⅲ 多糖 质量评价 

分 类 号：R917[医药卫生—药物分析学] R282[医药卫生—药学]