猪苓利水渗湿的药效物质、药理作用机制及临床应用研究进展  

Research progress on effective components,pharmacological mechanisms and clinical use of Polyporus umbellatus in diuresis-promotion and dampness-clearance

作　　者：鲁文静[1] 任慧[1] 崔小敏[1] 胡静 曲彤 李宁 陈志永 LU Wenjing;REN Hui;CUI Xiaomin;HU Jing;QU Tong;LI Ning;CHEN Zhiyong(Shaanxi Academy of Traditional Chinese Medicine,Xi’an 710003,China)

机构地区：[1]陕西省中医药研究院,西安710003

出　　处：《中国药房》2023年第11期1399-1403,共5页China Pharmacy

基　　金：陕西省自然科学基础研究计划项目(No.2020JQ-986);陕西省科协企业创新争先青年人才托举计划项目(No.SWYY202229);西安市科技计划项目(No.22YXYJ0113)。

摘　　要：猪苓是我国传统常用的利水渗湿中药,主要含有甾体类、多糖类等活性成分,常用于治疗泌尿系统疾病。本文对猪苓利水渗湿药效物质基础、药理作用机制及临床应用研究进展进行综述,归纳出麦角甾酮、过氧麦角甾酮、麦角甾-7,22-二烯-3-酮等甾体类化合物和猪苓多糖PPS1、PPS2、PPS3、GUMP-1-1、GUMP-1-2等可通过利尿、肾脏保护、抗炎、抗菌及免疫调节等药理作用发挥利水渗湿作用,猪苓散、猪苓汤、五苓散等中药复方制剂在治疗尿路感染或结石、肾性水肿、肾脏病变等方面效果显著,可为猪苓的进一步开发应用提供参考。Polyporus umbellatus,as a traditional Chinese medicine for promoting diuresis and clearing dampness,mainly contains steroids and polysaccharides.It is usually used to treat diseases of urinary system.In this paper,the research progress of the effective components,pharmacological mechanisms and clinical use of P.umbellatus in diuresis-promotion and dampnessclearance is reviewed.Steroids such as ergosterone,peroxyergosterone,ergosta-7,22-dien-3-one and P.umbellatus polysaccharide PPS1,PPS2,PPS3,GUMP-1-1 and GUMP-1-2 promote diuresis and eliminate dampness through diuresis,renal protection,antiinflammatory,bacteriostatic and immunomodulatory effects.Traditional Chinese medicine compound preparations such as P.umbellatus powder,P.umbellatus decoction,and Wuling powder have significant effects in treating urinary tract infections,lithiasis,renal edema and lesions,which providing reference for the further development and application of P.umbellatus.

关 键 词：猪苓 利水渗湿 药效物质 甾体类化合物 猪苓多糖 

分 类 号：R917[医药卫生—药物分析学] R965[医药卫生—药学]