Nod样受体蛋白3炎性小体的代谢调控及其在肾脏疾病中的作用  

Metabolic regulation of Nod-like receptor protein 3 inflammasome and its role in renal diseases

作　　者：王敏[1] 黄照辉 朱永红 李鑫 刘悦[1] 何萍[1] 马天魁 范秋灵[1,4] Wang Min;Huang Zhaohui;Zhu Yonghong;Li Xin;Liu Yue;He Ping;Ma Tiankui;Fan Qiuling(Department of Nephrology,the First Affiliated Hospital of China Medical University,Shenyang 110001,China;Department of Nephrology,the Fourth Affiliated Hospital of China Medical University,Shenyang 110032,China;Institute of Tumor Biological Therapy,the First Affiliated Hospital of China Medical University,Shenyang 110001,China;Department of Nephrology,First People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)

机构地区：[1]中国医科大学附属第一医院肾内科,沈阳110001 [2]中国医科大学附属第四医院肾内科,沈阳110032 [3]中国医科大学附属第一医院肿瘤生物治疗室,沈阳110001 [4]上海交通大学医学院附属第一人民医院肾内科,上海200080

出　　处：《中华肾脏病杂志》2023年第4期305-311,共7页Chinese Journal of Nephrology

基　　金：国家自然科学基金(82070754、81770724);兴辽计划科技创新领军人才基金(辽宁省特聘教授)(XLYC1902080)。

摘　　要：近年来随着代谢重编程领域研究的不断深入,人们对免疫细胞生物学效应的认识发生了转变,即在炎性反应刺激下,免疫细胞重新调控其代谢和生物能量学,提供细胞生存的能量和底物,启动免疫效应功能。Nod样受体蛋白3(Nod-like receptor protein 3,NLRP3)炎性小体作为先天免疫系统的重要组成部分,已被证明可以感知如尿酸和胆固醇晶体等代谢物,并可被代谢产物酮体所抑制;也受线粒体活性氧和糖酵解成分(如己糖激酶)的调节。最近的研究表明,多种代谢途径汇聚为NLRP3炎性小体的有效调控因子。该文综述了NLRP3炎性小体激活的代谢调节途径和特异性,以及其在肾脏疾病中的作用。In recent years,with the development of metabolic reprogramming research,people have changed their understanding of the biological effects of immune cells.Under the stimulation of inflammatory response,immune cells re-regulate their metabolism and bioenergetics,provide energy and substrates for cell survival,and initiate immune effect functions.Nod-like receptor protein 3(NLRP3)inflammasome,as an important component of the innate immune system,has been shown to sense metabolites such as uric acid and cholesterol crystals,and can be inhibited by metabolites such as ketones.It is also regulated by mitochondrial reactive oxygen species and glycolytic components(such as hexokinase).Recent studies have shown that a variety of metabolic pathways converge as effective regulators of NLRP3 inflammasome.The paper reviews the metabolic regulatory pathways and specificity of NLRP3 inflammasome activation,and its role in renal diseases.

关 键 词：糖酵解 炎性体 NLR家族 热蛋白结构域包含蛋白3 柠檬酸循环 新陈代谢 

分 类 号：R692[医药卫生—泌尿科学]