慢性肾脏病合并丙型肝炎病毒感染诊断、治疗和预防的临床实践指南(2023年版)  

Clinical practice guideline for the diagnosis,treatment and prevention of hepatitis C virus infection in patients with chronic kidney disease(2023)

作　　者：慢性肾脏病合并丙型肝炎病毒感染诊断、治疗和预防专家组 梅长林 张文宏 戴兵 Experts group on the diagnosis,treatment and prevention of hepatitis C virus infection in patients with chronic kidney disease Author information;Mei Changlin;Zhang Wenhong(不详;Division of Nephrology,Changzheng Hospital,Naval Medical University,Shanghai 200003,China;Division of Infectious Disease,Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]不详 [2]海军军医大学第二附属医院(上海长征医院)肾脏病科,上海200003 [3]复旦大学附属华山医院感染科,上海200040 [4]海军军医大学第二附属医院

出　　处：《中华肾脏病杂志》2023年第4期312-324,共13页Chinese Journal of Nephrology

摘　　要：丙型肝炎病毒(hepatitis C virus,HCV)感染在慢性肾脏病(chronic kidney disease,CKD)患者中高发,且在抗HCV治疗方面CKD患者具有特殊性。随着直接抗病毒药物(direct-acting antiviral agent,DAA)问世并广泛应用于临床,CKD患者合并HCV感染的预后得到了极大的改善。近年来HCV治疗领域研究进展迅速,多种DAA相继在国内获批上市。为此,我国肾脏病科、感染病科、肝脏病科和医院感控科专家在2019年发表的《CKD合并HCV感染诊断及治疗的专家共识》基础上,以国内外临床研究进展为依据,结合现阶段我国实际情况,更新形成了该指南,以期为CKD合并HCV感染患者的规范化诊治提供指导性建议。Hepatitis C virus(HCV)infection is of high prevalence among patients with chronic kidney disease(CKD).There are many unique features in anti-HCV treatment of the CKD patients.With the advent of direct-acting antiviral agents(DAAs)and their widely application in clinical practice,the prognosis of CKD patients with HCV infection has been greatly improved.In recent years,rapid progress has been made in HCV treatment,and many DAAs have been approved for marketing in China.Therefore,based on the expert consensus for the diagnosis,treatment,and prevention of hepatitis C virus infection in patients with chronic kidney disease published in 2019,combined with the domestic and foreign progress of clinical research and the national situation in China at present,a panel of experts specialized in nephrology,infectious disease,hepatology and infection control have updated and issued this guideline,to provide guidance for the standardized diagnosis and treatment of HCV infection in CKD patients.

关 键 词：肝炎 丙型 肝炎病毒属 丙型肝炎抗体 慢性肾脏病 诊断 治疗学 预防 指南 

分 类 号：R512.63[医药卫生—内科学] R692[医药卫生—临床医学]