黄芪当归贴膏对维持性血液透析患者自体动静脉内瘘的保护作用  

Protective effect of Astragalus Angelica ointment on autogenous arteriovenous fistula in patients with maintenance hemodialysis

作　　者：李峻 林莉 王俭梅 李芬 刘莉莉 汪星玉 丁洁 Jun Li;Li Lin;Jianmei Wang;Fen Li;Lili Liu;Xingyu Wang;Jie Ding(Hemodialysis Ward,Wuhan Third Hospital/Tongren Hospital of Wuhan University,Wuhan 430060,Hubei Province,China)

机构地区：[1]武汉市第三医院/武汉大学同仁医院血透室,430060

出　　处：《中华肾病研究电子杂志》2023年第2期87-92,共6页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

基　　金：武汉市卫生和计划生育委员会科研项目(WZ18D03)。

摘　　要：目的探讨黄芪当归贴膏联合个体化处理对维持性血液透析(MHD)患者自体动静脉内瘘(AVF)的影响。方法选取2019年3月至2021年5月我院收治的行AVF的MHD患者,随机分为观察组87例和对照组89例。对照组给予个体化处理,观察组在对照组基础上外敷黄芪当归贴膏,治疗2周。比较两组患者干预前后血管直径、吻合口血流量和AVF管路通畅率,以及血清低氧诱导因子-1α(HIF-1α)、血小板衍生生长因子(PDGF)和血管内皮生长因子(VEGF)水平及AVF并发症。结果治疗后,两组血管直径和吻合口血流量均增大,且观察组更为明显(P<0.05),观察组的AVF管路通畅率高于对照组(P<0.05),观察组的HIF-1α、VEGF和PDGF亦明显升高(P<0.05)。观察组的AVF并发症发生率(6.90%)显著低于对照组(25.84%)(P<0.05)。结论黄芪当归贴膏对MHD患者可能具有改善AVF血流、减少AVF并发症的作用。Objective To investigate the effect of Astragalus Angelica ointment combined with individualized intervention on autologous arteriovenous fistula(AVF)in patients with maintenance hemodialysis(MHD).Methods MHD patients with AVF admitted from March 2019 to May 2021 were randomly divided into observation group(87 cases)and control group(89 cases).The control group was given individualized intervention,and the observation group was treated with Astragalus Angelica ointment combined with the individualized intervention for 2 weeks.The two groups were compared in vessel diameter,anastomotic blood flow,AVF patency rate,serum levels of hypoxia-inducible factor-1α(HIF-1α),platelet-derived growth factor(PDGF)and vascular endothelial growth factor(VEGF),as well as AVF complications.Results After treatment,the blood vessel diameter and anastomotic blood flow of both groups were increased,especially in the observation group(P<0.05).The patency rate of AVF of the observation group was higher than that of the control group(P<0.05).After treatment,the serum levels of HIF-1α,VEGF and PDGF in the observation group were also significantly increased(P<0.05).The AVF complication rate of the observation group(6.90%)was apparently lower than that of the control group(25.84%)(P<0.05).Conclusion The Astragalus Angelica ointment may have an effect in improving the AVF blood flow and reducing the AVF complications in the MHD patients.

关 键 词：维持性血液透析 自体动静脉内瘘 黄芪当归贴膏 保护作用 

分 类 号：R692[医药卫生—泌尿科学]