谷氨酸与谷氨酰胺类似物PET显像剂研究进展  

Research progress of glutamate and glutamine analog PET imaging agents

作　　者：梁浩然 徐万帮[2] 唐刚华[3] Liang Haoran;Xu Wanbang;Tang Ganghua(School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China;Department of Traditional Chinese Medicine,Guangdong Institute for Drug Control,Guangzhou 510663,China;Key Laboratory for Quality Control and Evaluation of Radiopharmaceuticals,Guangdong Provincial Drug Administration,Department of Nuclear Medicine,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学药学院,广州510515 [2]广东省药品检验所中药室,广州510663 [3]南方医科大学,南方医院核医学科,广东省药品监督管理局放射性药物质量控制与评价重点实验室,广州510515

出　　处：《国际放射医学核医学杂志》2023年第3期175-181,共7页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金重大研发计划(91949121);广东省基础与应用基础研究基金(2022A1515010072);南方医院引进人才启动基金(123456)。

摘　　要：谷氨酰胺是血浆中浓度最高的氨基酸,肿瘤细胞的生长与增殖依赖于谷氨酰胺及其中间代谢产物(如谷氨酸、乳酸、脯氨酸、氨等),肿瘤细胞的生长速度与细胞内谷氨酰胺和谷氨酸的浓度密切相关,谷氨酰胺与谷氨酸在肿瘤代谢中起着重要作用。肿瘤细胞摄取谷氨酸与谷氨酰胺类似物PET显像剂的机制主要涉及氨基酸转运与蛋白质合成。谷氨酸与谷氨酰胺类似物PET显像剂在肝细胞癌、脑肿瘤、胶质瘤以及其他多种肿瘤的鉴别诊断中具有优势,可以弥补 18F-氟脱氧葡萄糖PET显像的一些不足。笔者主要对谷氨酸与谷氨酰胺类似物PET显像剂的研究进展进行综述。Glutamine has the highest concentration of amino acid in plasma,and the growth and proliferation of tumor cells depend on glutamine and its intermediate metabolites,such as glutamate,lactate,proline,and ammonia.The growth rate of tumor cells is closely related to the intracellular concentrations of glutamine and glutamate,which play an important role in tumor metabolism.The mechanism of glutamate and glutamine analog PET imaging agents uptaked by tumor cells primarily involves amino acid transport and protein synthesis.Glutamate and glutamine analog PET imaging agents have advantages in the differential diagnosis of hepatocellular carcinoma,brain tumors,glioma,and many other tumors,which can compensate for some deficiencies of 18Ffluorodeoxyglucose PET imaging.This paper primarily reviews the research progress of glutamate and glutamine analog PET imaging agents.

关 键 词：谷氨酸 谷氨酰胺 类似物 正电子发射断层显像术 放射性示踪剂 

分 类 号：R981[医药卫生—药品] TQ421.7[医药卫生—药学]