功能化小尺寸IrO_(2)纳米颗粒的制备及其光动力学治疗研究  

Preparation of Functionalized Small-size IrO_(2) Nanoparticles for Photodynamic Therapy

作　　者：席茹洁 乔湘凯 阿不都卡德尔·阿不都克尤木 Xi Rujie;Qiao Xiangkai;Abdukader Abdukayum(College of Chemistry and Environmental Sciences,Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry,Kashi University,Kashi 844000,China)

机构地区：[1]喀什大学化学与环境科学学院,新疆特色药食用植物资源化学自治区重点实验室,新疆喀什844000

出　　处：《南开大学学报（自然科学版）》2023年第2期99-104,共6页Acta Scientiarum Naturalium Universitatis Nankaiensis

基　　金：新疆维吾尔自治区高校科研计划(XJEDU2018I017);新疆维吾尔自治区自然科学基金(2022D01E16)。

摘　　要：光动力学疗法在肿瘤的微创和高效治疗中得到了广泛的应用.但是,大部分光敏剂纳米材料的尺寸较大,以及产生单线态氧的产生能力较弱,因而限制了其在肿瘤治疗中的进一步应用.氧化铱(IrO_(2))作为一种半导体材料,因其具有较好的光催化性能,而被研发应用于光动力学治疗.采用水解法,制备出具有小尺寸的IrO_(2)纳米颗粒(NPs).为进一步提升IrO_(2) NPs的生物相容性、通过结合聚乙二醇(PEG)分子,得到IrO_(2)-PEG NPs.通过紫外-可见光谱、傅里叶红外光谱、X-射线衍射、透射电子显微镜、X-射线能谱元素分析、Zeta电位分析、动态光散射分析、热重分析和X-射线光电子能谱,分析和讨论了IrO_(2)-PEG NPs.结果表明,IrO_(2)-PEG具有良好的生物相容性和光动力治疗作用,在肿瘤治疗方面具有很大的应用前景.Photodynamic therapy has been widely used in the minimally invasive and efficient treatment of tumors. However, the large size and the weak ability to generate singlet oxygen production of most photosensitizer nanomaterials have limited their further application in tumor therapy. Iridium oxide(IrO_(2)), a semiconductor material, has been developed for photodynamic therapy applications because of its better photocatalytic properties. In this paper, IrO_(2) nanoparticles(NPs) with small size were prepared by hydrolysis method. To further enhance the biocompatibility of IrO_(2) NPs, IrO_(2)-PEG NPs were obtained by incorporating polyethylene glycol(PEG) molecules. IrO_(2)-PEG NPs were analyzed and discussed by UV-Vis spectroscopy, FTIR, X-ray diffraction, transmission electron microscopy, X-ray energy spectrum elemental analysis, zeta potential analysis, dynamic light scattering analysis, thermo gravimetric analysis, X-ray photoelectron spectroscopy. The experimental results show that IrO_(2)-PEG has good biocompatibility and photodynamic therapeutic effects. It has great application prospects in tumor treatment.

关 键 词：氧化铱 纳米颗粒 光动力治疗 PEG 小尺寸 

分 类 号：O653[理学—分析化学]