Association of vitamin D and polymorphisms of its receptor with antiviral therapy in pregnant women with hepatitis B  

作　　者：Rui Wang Xia Zhu Xuan Zhang Huan Liu Yu-Lin Ji Yong-Hua Chen 

机构地区：[1]Division of Pancreatic Surgery,Department of General Surgery,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China [2]Center of Infectious Diseases,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China [3]Department of Respiratory and Critical Care Medicine,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China

出　　处：《World Journal of Gastroenterology》2023年第19期3003-3012,共10页世界胃肠病学杂志（英文版）

基　　金：Supported by the Key Research and Development Projects in Sichuan Province,No.2021YFS0168;the National Scientific and Technological Major Project for Infectious Diseases Control in China,No.2018ZX10715-003.

摘　　要：BACKGROUND The interruption of mother-to-child transmission(MTCT)is considered important to decrease the individual and population morbidity of hepatitis B virus(HBV)infection as well as the global burden of hepatitis B.Serum vitamin D(VD)is associated with hepatitis B.AIM To assess whether baseline VD levels and single nucleotide polymorphisms of the VD receptor gene(VDR SNPs)are associated with the efficacy of tenofovir disoproxil fumarate(TDF)in the prevention of MTCT in pregnant women with high HBV viral loads.METHODS Thirty-eight pregnant women who were at high risk for MTCT of HBV(those with an HBV DNA level≥2×10^(5)IU/mL during 12-24 wk of gestation)receiving antiviral therapy of TDF between June 1,2019 and June 30,2021 in Mianyang were included in this retrospective study.The women received 300 mg TDF once daily from gestational weeks 24-28 until 3 mo after delivery.To further characterize the clinical relevance of maternal serum HBV DNA levels,we stratified patients according to HBV DNA level as follows:Those with levels<2×10_(5)(full responder group)vs those levels≥2×10^(5)IU/mL(partial responder group)at delivery.Serum levels of 25-hydroxyvitamin D[25(OH)D],liver function markers,virological parameters,VDR SNPs and other clinical parameters were collected to analyze their association with the efficacy of TDF.The Mann-Whitney U test or t test was used to analyze the serum levels of 25(OH)D in different groups.Multiple linear regressions were utilized to analyze the determinants of the maternal HBV DNA level at delivery.Univariate and multivariate logistic regression analyses were employed to explore the association of targeted antiviral effects with various characteristics at baseline and delivery.RESULTS A total of 38 pregnant women in Mianyang City at high risk for MTCT of HBV were enrolled in the study.The MTCT rate was 0%.No mother achieved hepatitis B e antigen or hepatitis B surface antigen(HBsAg)clearance at delivery.Twenty-three(60.5%)participants were full responders,and 15(39.5%)partici

关 键 词：Hepatitis B virus Vitamin D Vitamin D receptor polymorphism Antiviral therapy PREGNANCY Mother-to-child transmission 

分 类 号：R512.62[医药卫生—内科学]