Chronic pulmonary mucormycosis caused by rhizopus microsporus mimics lung carcinoma in an immunocompetent adult:A case report  

作　　者：Xing-Zi Guo Liang-Hui Gong Wen-Xiang Wang De-Song Yang Bai-Hua Zhang Ze-Tao Zhou Xiao-Hui Yu 

机构地区：[1]Department of Gynecologic Oncology,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410031,Hunan Province,China [2]The Second Department of Thoracic Surgery,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410031,Hunan Province,China [3]GZMU-GIBH School of Life Sciences,Guangzhou Medical University,Guangzhou 511436,Guangdong Province,China [4]Department of Pathology,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410031,Hunan Province,China

出　　处：《World Journal of Clinical Cases》2023年第14期3295-3303,共9页世界临床病例杂志

基　　金：Supported by Hunan Provincial Natural Science Foundation of China,No.2022JJ40247,No.2022JJ40256。

摘　　要：BACKGROUND Pulmonary mucormycosis is a rare but life-threatening invasive fungal infection that mostly affects immunocompromised patients.This disease usually develops acutely and progresses rapidly,often leading to a poor clinical prognosis.Chronic pulmonary mucormycosis is highly unusual in immunocompetent patients.CASE SUMMARY A 43-year-old man,who was a house improvement worker with a long history of occupational dust exposure,presented with an irritating cough that had lasted for two months.The patient was previously in good health,without dysglycemia or any known immunodeficiencies.Chest computed tomography revealed a mass in the left lower lobe,measuring approximately 6 cm in diameter,which was suspected to be primary lung carcinoma complicated with obstructive pneumonia.Thoracoscopic-assisted left lower lobectomy was performed,and metagenomic next-generation sequencing detection,along with special pathological staining of surgical specimens,suggested Rhizopus microsporus infection.Postoperatively,the patient’s respiratory symptoms were relieved,and no signs of recurrence were found during the six-month follow-up.CONCLUSION This article reports a rare case of chronic pulmonary mucormycosis caused by Rhizopus microsporus in a middle-aged male without dysglycemia or immunodeficiency.The patient’s surgical outcome was excellent,reaffirming that surgery remains the cornerstone of pulmonary mucormycosis treatment.

关 键 词：Rhizopus microsporus Pulmonary mucormycosis Immunocompetent patient Surgical resection Case report 

分 类 号：R563[医药卫生—呼吸系统]