Causative bacteria of ventilator-associated pneumonia in intensive care unit in Bahrain:Prevalence and antibiotics susceptibility pattern  

作　　者：Mohamed Eliwa Hassan Safaa Abdulaziz Al-Khawaja Nermin Kamal Saeed Sana Abdulaziz Al-Khawaja Mahmood Al-Awainati Sara Salah Yusuf Radhi Mohamed Hameed Alsaffar Mohammed Al-Beltagi 

机构地区：[1]Intensive Care Unit,Department of Internal medicine,Salmaniya Medical Complex,Ministry of Health,Manama,Kingdom of Bahrain,Manama 12,Manama,Bahrain [2]Infectious Disease Unit,Department of Internal Medicine,Salmaniya Medical Complex,Ministry of Health,Kingdom of Bahrain,Manama 12,Manama,Bahrain [3]Medical Microbiology Section,Department of Pathology,Salmaniya Medical Complex,Ministry of Health,Kingdom of Bahrain,Manama 12,Manama,Bahrain [4]Medical Microbiology Section,Department of Pathology,Irish Royal College of Surgeon,Bahrain,Busiateen 15503,Muharraq,Bahrain [5]Department of Family Medicine,Ministry of Health,Manama,Kingdom of Bahrain,Manama 12,Manama,Bahrain [6]Department of Pediatrics,Faculty of Medicine,Tanta University,Tanta 31511,Alghrabia,Egypt [7]Department of Pediatrics,University Medical Center,King Abdulla Medical City,Arabian Gulf University,Dr.Sulaiman Al Habib Medical Group,Manama 26671,Manama,Bahrain

出　　处：《World Journal of Critical Care Medicine》2023年第3期165-175,共11页世界重症医学杂志

摘　　要：BACKGROUND Ventilator-associated pneumonia(VAP)is defined as pneumonia that occurs two calendar days following endotracheal intubation or after that.It is the most common infection encountered among intubated patients.VAP incidence showed wide variability between countries.AIM To define the VAP incidence in the intensive care unit(ICU)in the central gove-rnment hospital in Bahrain and review the risk factors and the predominant bacterial pathogens with their antimicrobial susceptibility pattern.METHODS The research was a prospective cross-sectional observational study over six months from November 2019 to June 2020.It included adult and adolescent patients(>14 years old)admitted to the ICU and required intubation and mechanical ventilation.VAP was diagnosed when it occurred after 48 h after endotracheal intubation using the clinical pulmonary infection score,which considers the clinical,laboratory,microbiological,and radiographic evidence.RESULTS The total number of adult patients admitted to the ICU who required intubation and mechanical ventilation during the study period was 155.Forty-six patients developed VAP during their ICU stay(29.7%).The calculated VAP rate was 22.14 events per 1000 ventilator days during the study period,with a mean age of 52 years±20.Most VAP cases had late-onset VAP with a mean number of ICU days before the development of VAP of 9.96±6.55.Gram-negative contributed to most VAP cases in our unit,with multidrug-resistant Acinetobacter being the most identified pathogen.CONCLUSION The reported VAP rate in our ICU was relatively high compared to the international benchmark,which should trigger a vital action plan for reinforcing the implementation of the VAP prevention bundle.

关 键 词：Ventilator-associated pneumonia Intensive care unit Antibiotics susceptibility pattern Kingdom of Bahrain Adults Bacterial resistance ACINETOBACTER 

分 类 号：R563.1[医药卫生—呼吸系统]