二氧化硅粉尘表面改性剂减轻矽肺纤维化的研究进展  

Research progress in effect of surface modifiers of silicon dioxide dusts on alleviating silicotic pulmonary fibrosis

作　　者：贺今 刘保岩 HE Jin;LIU Baoyan(Shandong Provincial Academy of Occupational Health and Occupational Medicine/Shandong First Medical University/Shandong Provincial Occupational Diseases Hospital,Jinan,Shandong 250062,China)

机构地区：[1]山东省职业卫生与职业病防治研究院/山东第一医科大学/山东省职业病医院,山东济南250062

出　　处：《中国工业医学杂志》2023年第2期153-156,共4页Chinese Journal of Industrial Medicine

基　　金：山东省自然科学基金(ZR2021MH178);山东省中医药科技项目(2021Q082);济南市科技计划后补助项目(202019203);山东医药卫生科技发展计划项目(202014050602)。

摘　　要：二氧化硅(SiO_(2))是致肺部纤维化最强的粉尘,致纤维化作用与其物理-化学表面活性密切相关,SiO_(2)粉尘表面改性剂可通过改变表面活性基团的特性、减少活性氧(ROS)的产生和抑制炎症反应减缓矽肺纤维化的发生。本文总结了SiO_(2)表面改性剂在减轻矽肺纤维化方面的研究进展,为预防矽肺发生发展提供潜在的预防和治疗策略。Silica dusts(silicon dioxide,SiO2)is the strongest dusts causing pulmonary fibrosis.Its fibrogenic effects are closely related to their physio⁃chemical surface activity,the surface modifiers of SiO_(2) dusts could change the characteristics of their surface active groups,reduce the production of reactive oxygen species(ROS),and inhibit inflammation reactions,thereby slowing down the occurrence of silicotic pulmonary fibrosis.This review summarizes the research progress of SiO_(2) surface modifi⁃ers in alleviating silicotic pulmonary fibrosis,thereby providing some potential prevention and treatment strategies for preventing the occurrence and development of silicosis.

关 键 词：二氧化硅(SiO_(2)) 表面改性剂 矽肺 纤维化 

分 类 号：R135.2[医药卫生—劳动卫生]