Ac-SDKP抑制动物模型肺纤维化的Meta分析  

Meta-analysis of Ac-SDKP inhibition of Pulmonary fibrosis in animal models

作　　者：巩海波 张成梅 唐新妍 宫若冰 苗智颖 邓海静 Gong Haibo;Zhang Chengmei;Tang Xinyan;Gong Ruobing;Miao Zhiying;Deng Haijing(School of Basic Medical Sciences,North China University of Science and Technology,Hebei Key Laboratory for Chronic Diseases,Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases,Tangshan 063210,China)

机构地区：[1]华北理工大学基础医学院,河北省慢性疾病基础医学重点实验室,唐山市老年慢性病临床基础研究重点实验室,唐山063210

出　　处：《中华劳动卫生职业病杂志》2023年第4期262-270,共9页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金(81302395);河北省高等学校科学技术研究重点项目(ZD2020340);华北理工大学博士科研启动项目;河北省自然科学基金培育基金;华北理工大学杰出青年基金项目。

摘　　要：目的通过Meta分析研究N-乙酰基-丝氨酰-天门冬氨酰-赖氨酰-脯氨酸(Ac-SDKP)对肺纤维化的抗纤维化作用。方法于2021年5月,检索中国知网、万方数据库、维普、中国生物医学文献数据库、PubMed、OVID数据库,检索时间为2008年1月至2021年5月,筛选关于Ac-SDKP抑制肺纤维化的随机对照试验,其中对照组为肺纤维化模型组,实验组为Ac-SDKP治疗组。采用SYRCLE风险偏倚评估工具进行文献质量评价,并提取数据,采用RevMan5.4软件进行数据分析。结果纳入文献18篇,总计动物模型428个。Meta分析结果显示:与对照组比较,实验组的α-平滑肌肌动蛋白(α-SMA)、Ⅰ型胶原、Ⅲ型胶原、转化生长因子-β(TGF-β)及结节面积各指标含量均降低[SMD=-2.44,95%CI(-3.71~-1.17),P=0.000]、[SMD=-5.36,95%CI(-7.13~-3.59),P=0.000]、[SMD=-3.07,95%CI(-4.13~-2.02);P= 0.000]、[SMD=-2.88,95%CI(-3.63~-2.14),P=0.000]、[SMD=-1.80,95%CI(-2.42~-1.18),P=0.000],羟脯氨酸含量更高[SMD=7.62,95%CI(4.90~10.33),P=0.000]。结论 Ac-SDKP对肺纤维化进程具有明显的抑制作用,并可能成为治疗肺纤维化的一种新的临床药物。Objective To systematically study the anti-fibrotic effect of N-acetyl-seryl-as partyl-lysyl-proline(Ac-SDKP)on pulmonary fibrosis.Methods In May 2021,a computer search was performed on CNKI,Wanfang Knowledge Service Platform,VIP.com,China Biomedical Literature Database,Pubmed,OVID and other databases.The retrieval time was from January 2008 to May 2021.Randomized controlled experiments on the inhibition of pulmonary fibrosis by Ac-SDKP were screened.The control group was the pulmonary fibrosis model group and the experimental group was the Ac-SDKP treatment group.The quality of the literature was assessed using the syrcle risk of bias assessment tool,and data were extracted.Data analysis was Performed using revman 5.4 software.Results 18 papers were included,with a total of 428 animal models.The results of meta analysis showed that the contents ofα-smooth muscle actin(α-SMA),type I collagen,typeⅢcollagen,transforming growth factor-β(TGF-β)and Nodule area in the exPerimental group were lower than those in the control grouP.[SMD=-2.44,95%CI(-3.71--1.17),P=0.000][SMD=-5.36,95%CI(-7.13--3.59),P=0.000][SMD=-3.07,95%CI(-4.13--2.02),P<0.000][SMD=-2.88,95%CI(-3.63--2.14),P=0.000][SMD=-1.80,95%CI(-2.42--1.18),P=0.000],the content of hydroxy proline in the experimental group was higher than that in the control group[SMD=7.62,95%CI(4.90-10.33),P=0.000],all indexes included in the literature were statistically significant.Conclusion Ac-SDKP has obvious inhibitory effect on the process of pulmonary fibrosis,and may become a new clinical drug for the treatment of pulmonary fibrosis.

关 键 词：N-乙酰基-丝氨酰-天门冬氨酰-赖氨酰-脯氨酸 矽肺 肺纤维化 动物模型 META分析 

分 类 号：R563[医药卫生—呼吸系统] R-332[医药卫生—内科学]