新型冠状病毒疫苗及治疗药物研究进展  

Progress in research on SARS-CoV-2 vaccine and drugs

作　　者：胡亮 王春花 李光军 申梁 HU Liang;WANG Chunhua;LI Guangjun;SHEN Liang(Department of Laboratory,People's Hospital of Xiangzhou District,Xiangyang,Hubei 441000,China;不详)

机构地区：[1]襄州区人民医院检验科,湖北襄阳441000 [2]湖北文理学院附属医院襄阳市中心医院医学检验部,湖北襄阳441000

出　　处：《中国病毒病杂志》2023年第2期136-142,共7页Chinese Journal of Viral Diseases

基　　金：国家自然科学基金项目(82002192);襄阳市中心医院科研项目(RC202006,2022YZ01)。

摘　　要：2019年以来新型冠状病毒在全球范围内造成大量感染和死亡病例。在疫情防控中,新型冠状病毒疫苗和治疗药物起到了极大的作用。目前新型冠状病毒感染的高峰已经过去,社会也恢复了正常有序的生活节奏,但是病毒并没有消失,还有各种变异毒株在国内外流行,疫苗和治疗药物的研发仍然不可或缺。本文总结了新型冠状病毒灭活疫苗、减毒疫苗、重组蛋白疫苗、病毒载体疫苗、核酸疫苗、病毒样颗粒疫苗的特点及临床试验结果,并且综述了国内外新型冠状病毒治疗药物的研究进展。District;Since 2019, SARS-CoV-2 has caused a large number of infections and deaths worldwide. Vaccines and drugs treating SARS-CoV-2 have played an important role in pandemic control. After the infection peak, the society has returned to its normal status recently. However, with variants of the virus still being prevalent both in China and abroad, the research on vaccines and anti-SARS-CoV-2 drugs are still indispensable. This article summarized the characteristics and clinical trial results of inactivated vaccine, live attenuated vaccine, recombinant protein vaccine, viral vector vaccine, nucleic acid vaccine, virus-like particle vaccine, and reviewed the progress in research on anti-SARS-CoV-2 drugs both at home and abroad.

关 键 词：新型冠状病毒感染 灭活疫苗 减毒疫苗 重组蛋白疫苗 病毒载体疫苗 mRNA疫苗 DNA疫苗 抗新冠病毒药物 

分 类 号：R373.1[医药卫生—病原生物学]