长链非编码RNA抗结核分枝杆菌感染功能的研究进展  

Research progress on long non-coding RNA’s anti infection function against Mycobacterium tuberculosis

作　　者：董静 史雨婷 潘丽萍[1] 张宗德[1] Dong Jing;Shi Yuting;Pan Liping;Zhang Zongde(Beijing Chest Hospital,Capital Medical University/Beijing Key Laboratory of Drug Resistant Tuberculosis/Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京胸科医院/耐药结核病研究北京市重点实验室/北京市结核病胸部肿瘤研究所,北京101149

出　　处：《中国防痨杂志》2023年第6期613-619,共7页Chinese Journal of Antituberculosis

基　　金：国家自然科学基金(82172279,81902024);通州区科技计划项目(KJ2022CX042);通州区运河计划人才项目(YH201807,YH202001)。

摘　　要：目前对于结核分枝杆菌(Mycobacterium tuberculosis,MTB)感染和结核病发病的免疫调控机制尚未完全阐明。长链非编码RNA(long non-coding RNA,lncRNA)是近年来结核病研究领域的重点关注对象之一,其可参与基因表达调控、细胞周期调节和细胞分化等多种生物学过程。研究结核病中异常表达的lncRNA在疾病发病及转归过程中的免疫调控作用,对于深入了解MTB感染和结核病发病过程中的宿主免疫应答机制具有重要意义。笔者综述近年来关于宿主lncRNA分子在MTB感染免疫调控过程中的作用和具体机制研究进展,为lncRNA介导的结核病宿主免疫治疗提供思路。The pathogenesis and immunological mechanism of Mycobacterium tuberculosis(MTB)infection and further development of active tuberculosis have not yet been fully elucidated.Recently,long non-coding RNA(lncRNA)has received more attention in MTB infection and active tuberculosis development study,for it is involved in a variety of biological processes,such as gene expression regulation,cell cycle regulation,cell differentiation,and so on.It is of great significance to illustrate the regulation mechanism of aberrant lncRNA in the developing and progression of tuberculosis,which could help us further understand the mechanism of host immunological response to MTB infection and progression.Therefore,we reviewed the research progress of impact and specific mechanisms of lncRNA affecting human immunological response to MTB infection,to facilitate future development of novel lncRNA-based immunotherapy of tuberculosis.

关 键 词：分枝杆菌 结核 感染 免疫 RNA 

分 类 号：R52[医药卫生—内科学] R392[医药卫生—临床医学]