长期低剂量核辐射接触人员机体相关指标变化  

Changes in body-related indices in people exposed to long-term low-dose nuclear radiation

作　　者：刘剑英 尚伟华 马得勋 邱霞 刘书锋 LIU Jianying;SHANG Weihua;MA Dexun;QIU Xia;LIU Shufeng(Qingdao Special Servicemen Recuperation Center of PLA Navy,Qingdao 266071 China;PLA Navy NO.971 Hospital,Qingdao 266071 China;State Key Laboratory of Marine Food Processing&Safety Control,Qingdao Brightmoon Seaweed Group Co.,Ltd.,Qingdao 266400 China)

机构地区：[1]海军青岛特勤疗养中心,山东青岛266071 [2]海军青岛九七一医院,山东青岛266071 [3]明月海藻集团有限公司海洋食品加工与安全控制全国重点实验室,山东青岛266400

出　　处：《中国辐射卫生》2023年第2期167-170,共4页Chinese Journal of Radiological Health

基　　金：军队后勤计划项目(AWS14C015;CJN15J001)。

摘　　要：目的 对核辐射低剂量长期接触人员进行抗氧化指标、免疫指标、淋巴细胞增殖活性和血生化等进行检测分析,探讨低剂量核辐射接触对机体的影响,为其辐射防护和职业健康监护提供依据。方法 选取80名核辐射作业的人员为接触组,另选30名非接触人员为对照组,分别检测血生化、血清总抗氧化能力(T-AOC)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、淋巴细胞增殖活性、增殖细胞核抗原(PCNA)、细胞凋亡因子Bcl-2和Bax、淋巴细胞转化率、淋巴细胞微核率等指标。结果 接触组T-AOC、GSH-Px、SOD、细胞增殖活性、PCNA、Bcl-2、淋巴细胞转化率、WBC、PLT与对照组相比明显降低;MDA、Bax与对照组相比明显增高,差异有统计学意义(P <0.05);淋巴细胞微核率二者比较无统计学意义(P> 0.05)。结论 核辐射长期低剂量接触对作业人员相关指标有一定影响,但未造成明显损伤,核辐射接触人员应增强防护意识,加强科学防护,降低辐射损伤。Objective To investigate the effects of low-dose nuclear radiation exposure on the body by analyzing the antioxidant indices,immune indices,lymphocyte proliferation activity,and blood biochemical indices of persons exposed to long-term low-dose nuclear radiation,and to provide a basis for radiation protection and occupational health monitoring.Methods Eighty nuclear radiation workers were selected as the exposure group,and another 30 non-exposure personnel were selected as the control group.In both groups,blood biochemistry,serum total antioxidant capacity(T-AOC),malondialdehyde(MDA),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),lymphocyte proliferation activity,proliferating cell nuclear antigen(PCNA),apoptosis factors Bcl-2 and Bax,lymphocyte transformation rate,and lymphocyte micronucleus rate were measured.Results Compared with the control group,T-AOC,GSH-Px,SOD,cell proliferation activity,PCNA,Bcl-2,lymphocyte transformation rate,white blood cell count,and platelet count in the exposure group were significantly decreased,while MDA and Bax were significantly increased(P<0.05).The lymphocyte micronucleus rate showed no significant difference between the two groups(P>0.05).Conclusion Long-term low-dose exposure to nuclear radiation has certain effects on related indices of workers,but does not cause significant damage.The personnel exposed to nuclear radiation should enhance the awareness of protection and strengthen scientific protection to reduce radiation damage.

关 键 词：核辐射接触人员 辐射损伤 细胞增殖活性 淋巴细胞微核率 

分 类 号：X591[环境科学与工程—环境工程]