PBAT微球的制备及其载药应用  

Preparation of PBAT Microspheres and Its Drug Loading Application

作　　者：谢川 韦元智 李泽阳 刘玉飞 余佳[4] 程莎[4] 韦仕南 曾晞 骆衡[4,5] XIE Chuan;WEI Yuanzhi;LI Zeyang;LIU Yufei;YU Jia;CHENG Sha;WEI Shinan;ZENG Xi;LUO Heng(College of Chemistry and Chemical Engineering,Guizhou University,Guiyang 550025,China;Department of Polymer Materials and Engineering,College of Materials and Metallurgy,Guizhou University,Guiyang 550025,China;National Engineering Research Center for Composite Modified Polymer Materials,Guiyang 550014,China;Key Laboratory of Natural Products Chemistry,Chinese Academy of Sciences,Guiyang 550014,China;State Key Laboratory of Medicinal Plant Efficacy and Utilization,Guizhou Medical University,Guiyang 550014,China)

机构地区：[1]贵州大学化学与化工学院,贵州贵阳550025 [2]贵州大学材料与冶金学院高分子材料与工程系,贵州贵阳550025 [3]国家复合改性聚合物材料工程技术研究中心,贵州贵阳550014 [4]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550014 [5]贵州医科大学药用植物功效与利用国家重点实验室,贵州贵阳550014

出　　处：《塑料工业》2023年第5期69-74,85,共7页China Plastics Industry

基　　金：贵州大学自然科学专项基金(贵大特岗合字(2021)44号);贵州省“百”层次创新型人才培养项目(编号黔科合平台人才-GCC[2022]034-1)。

摘　　要：本文采用静电喷雾法实现了聚己二酸对苯二甲酸丁二醇酯(PBAT)可生物降解中空微球的可控制备,并且通过加入聚乙烯醇缩丁醛(PVB)对其结构进行调控。而后用于药物负载进行了缓释研究,通过20 d的体外降解实验发现,PBAT/PVB微球的降解速率比纯PBAT微球快4.35%。然后将它们成功地用于负载厄洛替尼(市售抗癌药),经过3周的体外释放实验,添加PVB的微球比纯PBAT微球累积释放厄洛替尼快14.24%。Controllable preparation of polybutylene adipate terephthalate(PBAT)biodegradable hollow microspheres were achieved by electrostatic spray method and its structure was regulated by adding polyvinyl butyral(PVB).Through 20 d of in vitro degradation experiments,it is found that the degradation rate of PBAT/PVB microspheres is 4.35%faster than that of pure PBAT microspheres.Then they are successfully used to load erlotinib(a commercially available anticancer drug).After 3 weeks of in vitro release experiments,the cumulative release of erlotinib from PVB-added microspheres is 14.24%faster than that of pure PBAT microspheres.

关 键 词：中空微球 静电喷雾 聚己二酸/对苯二甲酸丁二醇酯纤维 生物可降解 

分 类 号：TQ325[化学工程—合成树脂塑料工业]