人体菌群与肺动脉高压的研究进展与展望  

Human Microbiota and Pulmonary Hypertension

作　　者：柳民 夏健明[1] 王昱冕 赵敏章 邓瑶 任浩博 赵勇 张宇[1] 马润伟[1] LIU Min;XIA Jianming;WANG Yumian;ZHAO Minzhang;DENG Yao;REN Haobo;ZHAO Yong;ZHANG Yu;MA Runwei(Fuwai Yunnan Cardiovascular Hospital,The Affiliated Cardiovascular Hospital of Kunming Medical University,Kunming 650102,Yunnan,China;Graduate School of Kunming Medical University,Kunming 650000,Yunnan,China)

机构地区：[1]昆明医科大学附属心血管病医院云南省阜外心血管病医院,云南昆明650102 [2]昆明医科大学研究生院,云南昆明650000

出　　处：《心血管病学进展》2023年第5期453-456,共4页Advances in Cardiovascular Diseases

基　　金：云南省心血管病临床医学中心项目(FZX2019-06-01);云南省心血管系统疾病临床医学研究中心-重大心血管疾病诊治新技术研发项目(202102AA310002)。

摘　　要：微生物群在人体健康和疾病的发生发展过程中发挥着重要作用,微生物群稳态及相关代谢产物丰度变化可导致宿主发生一系列生理与病理变化。肺动脉高压(PH)是肺血管系统疾病之一,发病率和死亡率均很高,PH患者如不能得到及时治疗,最终可发展为右心衰竭甚至死亡。近年研究发现,咽部菌群、肺部菌群、肠道菌群与PH的发生发展过程密切相关。现阐述咽部菌群、肺部菌群和肠道菌群与PH之间的关系。The microbiota plays an important role in the occurrence and development of human health and disease,and changes in the homeostasis and abundance of related metabolite in the microbiota can lead to a series of physiological and pathological changes in the host.Pulmonary hypertension(PH)is one of the pulmonary vascular system diseases with high morbidity and mortality,and patients with PH can eventually develop right heart failure or die if they do not receive timely treatment.In recent years,it has been found that pharyngeal flora,pulmonary flora and intestinal flora are closely related to the occurrence and development of PH.The relationship between pharyngeal flora,pulmonary flora and intestinal flora and PH is now described.

关 键 词：肺动脉高压 咽部菌群 肺部菌群 肠道菌群 

分 类 号：R544.1[医药卫生—心血管疾病]