小鼠成骨细胞对高加速度力学微环境的弹性响应  

Elastic Response of Osteoblasts to Hypergravity

作　　者：杨文凯 王鑫[2] YANG Wenkai;WANG Xin(Tianjin Key Laboratory of Advanced Electromechanical System Design and Intelligent Control,Tianjin University of Technology,Tianjin 300384;National Experimental Teaching Demonstration Center of Mechanical and Electrical Engineering(Tianjin University of Technology),Tianjin 300384)

机构地区：[1]天津理工大学天津市先进机电系统设计与智能控制重点实验室,天津300384 [2]机电工程国家级实验教学示范中心(天津理工大学),天津300384

出　　处：《中国科技纵横》2023年第8期96-98,共3页China Science & Technology Overview

基　　金：天津市研究生科研创新项目“高加速度力学微环境对小鼠成骨细胞的生物力学响应”(2019YJSS054)。

摘　　要：在载人航天器发射与返回、现代高性能战斗机的起飞与降落等国家重大军事行动和科研探索时,航天员和飞行员均暴露于高加速度的极端力学环境中,但是极端力学微环境对骨组织等人体器官所产生的影响至今还没有得到充分的认识。本文采用小鼠成骨细胞作为模型,利用之前研发的力学加载装置对细胞进行加载,进而研究力学因素在骨组织重建过程中所起到的关键性作用。利用原子力显微镜对细胞进行力学加载实验从而得出细胞的力学响应,采用经典Hertzian接触力学模型拟合细胞加载曲线,进行得出细胞的弹性模量,得出细胞的弹性性质。本文的研究结果为组织工程中研究高加速度力学加载微环境下骨组织的力学生物学响应提供了可靠的理论依据,并具有指导意义。Astronauts and pilots in the extreme mechanical environment of high acceleration in the launch and return of manned spacecraft,the take-off and landing of modern high-performance aircraft and other major national military operations,causing great damage to human organs such as bones.Therefore,it is of great theoretical and practical significance to study the cells in the extreme mechanics micro-environment with high acceleration.In this paper,MC3T3-E1 murine pre-osteoblastic cell is used as cellular model.A pre-developed experimental equipment is used to simulate the osteoblasts in the high acceleration mechanics micro-environment in order to study the role of mechanical factors in the process of bone tissue reconstruction.Cellular elastic properties by AFM stating elastic mechanical properties fitted by Hertz model.The results showed in this dissertation,provides a theoretical basis for the study of the effect of high gravity on bone tissue reconstruction in tissue engineering.

关 键 词：成骨细胞 弹性 细胞形态 力学生物学响应 

分 类 号：R336[医药卫生—人体生理学]