彝族药固公果根化学成分和药理活性研究进展及其质量标志物预测分析  

Research Advances on Chemical Constituents and Pharmacological Activities of Rosa odorata Sweet var.gigantean Root and the Predictive Analysis of Quality Markers

作　　者：康荣 程显隆[1] 高智慧 周立鹏 刘越 魏锋[1] 马双成[1] Kang Rong;Cheng Xianlong;Gao Zhihui;Zhou Lipeng;Liu Yue;Wei Feng;Ma Shuangcheng(National Institutes for Food and Drug Control,Beijing 100050,China;College of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]中国食品药品检定研究院,北京100050 [2]北京中医药大学中药学院,北京102488

出　　处：《中国药事》2023年第5期563-573,共11页Chinese Pharmaceutical Affairs

基　　金：国家重点研发计划“中药材净切制关键技术与智能设备研究及应用”(编号2019YFC1711500)。

摘　　要：目的:基于中药质量标志物(Quality Maker,Q-marker)理论,预测固公果根的Q-marker,为固公果根建立科学的质量控制方法提供依据。方法:结合固公果根化学成分、质量控制、药理学研究,从原植物亲缘学及化学成分特有性、传统功效及药性和新的药效用途等多角度分析和预测固公果根Q-marker的候选化合物。结果与结论:固公果根主要为三萜类、鞣质、酚酸、黄酮类和甾体类等化合物,具抑菌、抗炎、调节胃肠功能等现代药理活性,但质量控制环节较为薄弱。综合Q-marker相关理论,建议考虑将固公果根药材中7个三萜类成分(2α,3α,19α,23-四羟基-熊果-12-烯-28-羧酸-28-O-β-D-吡喃葡萄糖酯苷、野蔷薇苷、蔷薇酸、冬青苷B、绢毛榄仁苷、熊果酸、齐墩果酸)和4个鞣质、酚酸类成分(儿茶素、原花青素B3、没食子酸、鞣花酸)作为固公果根药材Q-marker的候选化合物。Objective:Based on the theory of quality marker(Q-marker)of traditional Chinese medicine,to predict the Q-marker of Rosa odorata Sweet var.gigantean root,so as to provide a scientifi c basis for the establishment of its quality control method.Methods:Combined with the chemical constituents,quality control and pharmacological studies of Rosa odorata Sweet var.gigantean root,the candidate compounds of Q-markers were analyzed and predicted from the perspectives of original plant consanguinity,chemical composition peculiarity,traditional efficacy and medicinal properties and new medicinal uses.Results and Conclusion:Triterpenes,tannins,phenolic acids,flavonoids and steroids are the main compounds in the Rosa odorata Sweet var.gigantean root,which have antibacterial,anti-infl ammatory,gastrointestinal function regulation and other modern pharmacological activities,whereas the quality control link is relatively weak.By synthesizing the relevant theory of Q-marker,7 compounds of triterpenes(2α,3α,19α,23-tetrahydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester,rosamultin,euscaphic acid,Ilexin B,sericoside,ursolic acid,oleanolic acid)and 4 compounds of phenolic acids and tannins(catechin,procyanidin B3,gallic acid,ellagic acid)were recommended as the candidate compounds for Q-marker.

关 键 词：固公果根 化学成分 质量控制 药理活性 中药质量标志物 

分 类 号：R917[医药卫生—药物分析学]