CHD患者循环血浆Hep水平与冠状动脉病变程度的相关性  

Correlation between circulating plasma Hep level and coronary artery lesion in patients with CHD

作　　者：郑健康 苟峻琦 王玉泉[1] 何文凤[1] 曾建辉[1] 杨颖[1] 吕湛[1] ZHENG Jian-kang;GOU Jun-qi;WANG Yu-quan;HE Wen-feng;ZENG Jian-hui;YANG Ying;LV Zhan(Department of Cardiology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院附属医院心内科,四川南充637000

出　　处：《川北医学院学报》2023年第5期616-620,共5页Journal of North Sichuan Medical College

基　　金：四川省卫健委科研课题项目(20PJ153)。

摘　　要：目的:探讨血浆铁调素(Hep)水平与冠心病(CHD)的相关性。方法:选取行冠状动脉造影术且确诊为CHD的患者为研究者对象并设为CHD组(n=166),并选取同期冠脉造影结果阴性的患者为对照组(n=76)。比较两组患者血浆Hep水平及相关临床指标;分析CHD患者血浆Hep水平与Gensini积分的相关性;根据Gensini评分将患者分为低危组(n=58)、中危组(n=54)及高危组(n=54),分析血浆Hep水平是否为CHD的危险因素。结果:CHD患者血浆Hep浓度高于对照组(P<0.05)。对照组与Gensini积分低危组血浆Hep水平低于中危组及高危组(P<0.05)。相关性研究中,Hep与氧化低密度脂蛋白(Ox-LDL)呈正相关(P<0.05);Hep、Ox-LDL与Gensini评分呈正相关(P<0.05)。Logistic回归分析显示,Hep水平是影响发生CHD的危险因素(P<0.05)。结论:血浆Hep水平与CHD及冠脉病变程度呈正相关,Hep可能在CHD发病中起促进作用,血浆Hep浓度可作为预测冠脉病变程度的指标。Objective:To explore the correlation between plasma hepcidin(HEP)level and coronary heart disease(CHD).Methods:A total of 166 patients with CHD diagnosed by coronary angiography were selected as the CHD group,and 76 patients with negative coronary angiography results in the same period were selected as the control group.The plasma Hep levels and related clinical indicators between two groups of patients were compared,the correlation between plasma Hep levels and Gensini scores in CHD patients were analyzed.According to the Gensini score,patients were divided into low-risk group(n=58),medium risk group(n=54),and high-risk group(n=54)to analyze whether plasma Hep levels were risk factor for CHD.Results:The plasma Hep concentration in CHD group was higher than that in control group(P<0.05).The plasma Hep level in normal coronary artery group and low risk group with Gensini score was lower than that in medium risk group and high risk group(P<0.05).In the correlation study,Hep was positively correlated with oxidized low density lipoprotein(Ox-LDL)(P<0.05),Hep,Ox-LDL were positively correlated with Gensini score(P<0.05).Logistic regression analysis showed that Hep level was a risk factor for CHD(P<0.05).Conclusion:Plasma Hep level is positively correlated with CHD and the degree of coronary artery disease,Hep may play a role in promoting the pathogenesis of CHD,Plasma Hep concentration can be used as an index to predict the degree of coronary artery disease.

关 键 词：冠心病 铁调素 GENSINI评分 危险因素 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]