5-氨基酮戊酸光动力疗法联合液氮冷冻治疗男性复发性肛周尖锐湿疣的疗效  

Efficacy of ALA-PDT combined with liquid nitrogen cryotherapy for male recurrent perianal condyloma acuminatum

作　　者：李娜[1] 马蕾[1] 任娜[1] 安荣真[1] 李媛[1] 胡海友[1] LI Na;MA Lei;REN Na;AN Rong-zhen;LI Yuan;HU Hai-you(Department of Dermatology,Binzhou Medical University Hospital,Binzhou 256600,Shandong,China)

机构地区：[1]滨州医学院附属医院皮肤科,山东滨州256600

出　　处：《川北医学院学报》2023年第5期644-647,共4页Journal of North Sichuan Medical College

基　　金：山东省医药卫生科技发展计划(2019WS326)。

摘　　要：目的:探讨5-氨基酮戊酸光动力疗法(ALA-PDT)联合液氮冷冻治疗男性复发性肛周尖锐湿疣的疗效及安全性。方法:选取86例男性复发性肛周尖锐湿疣患者为研究对象,按照治疗方案不同分为对照组(n=43)与观察组(n=43)。对照组患者给予液氮冷冻治疗;观察组患者在对照组的基础上联合ALA-PDT治疗,两组均治疗4周。治疗后随访6个月,比较两组患者皮肤受损面积、性功能、复发及不良反应发生情况。结果:治疗后,两组患者皮肤受损面积均较治疗前缩小(P<0.05),且观察组小于对照组(P<0.05)。治疗后6个月,观察组患者治疗有效率高于对照组(88.37%vs.69.77%,P<0.05)。治疗后1、3、6个月,观察组患者国际勃起功能障碍指数(IIEF-5)评分均高于对照组(P<0.05)。治疗后1、3、6个月,观察组患者复发率均低于对照组(P<0.05)。两组中重度疼痛、排便疼痛、瘙痒、水肿及大便出血等不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:相较于单独行液氮冷冻治疗,ALA-PDT联合液氮冷冻治疗有利于促进男性复发性肛周尖锐湿疣患者皮肤愈合及性功能恢复、降低复发率,临床疗效更优且不增加不良反应发生风险。Objective:To investigate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy(ALA-PDT)combined with liquid nitrogen cryotherapy in the treatment of male recurrent perianal condyloma acuminatum.Methods:86 male patients with recurrent perianal condyloma acuminatum were selected as the study objects.They were divided into control group(n=43)and observation group(n=43)according to different treatment plans.The control group was given liquid nitrogen cryotherapy.The observation group was combined with ALA-PDT on the basis of the control group.The treatment time was 4 weeks,and the follow-up period was 6 months after treatment.The area of skin damage,sexual function,recurrence,and incidence of adverse reactions were compared between two groups.Results:After treatment,the area of skin damage in both groups was smaller than that before treatment(P<0.05),and the observation group was smaller than the control group(P<0.05).6 months after treatment,the effective rate of patients in the observation group was higher than that in the control group(88.37%vs.69.77%,P<0.05).At 1,3 and 6 months after treatment,the score of international index of erectile function(IIEF-5)in the observation group was higher than that in the control group(P<0.05).At 1,3 and 6 months after treatment,the recurrence rate of patients in the observation group was lower than that in the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions such as moderate and severe pain,defecation pain,itching,edema and stool bleeding between the two groups(P>0.05).Conclusion:Compared with liquid nitrogen cryotherapy alone,ALA-PDT combined with liquid nitrogen cryotherapy is beneficial to reduce the area of skin damage,promote the recovery of sexual function and reduce the recurrence rate of male patients with recurrent perianal condyloma acuminatum.The clinical effect is better and does not increase the risk of adverse reactions.

关 键 词：光动力疗法 液氮冷冻 男性 复发性肛周尖锐湿疣 不良反应 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]