血清Lp(a)、CX3CL1水平与冠心病严重程度的关系及诱发疾病的危险因素  

Relationship between serum Lp(a),CX3CL1 levels and the severity of coronary heart disease and its risk factors for inducing disease

作　　者：张泳仪 莫伟平 刘敏霞 ZHANG Yong-yi;MO Wei-ping;LIU Min-xia(Department of Laboratory,Dongguan People's Hospital,Dongguan Hospital Affiliated to Southern Medical University,Dongguan 523000,Guangdong,China)

机构地区：[1]南方医科大学附属东莞医院·东莞市人民医院检验科,广东东莞523000

出　　处：《川北医学院学报》2023年第5期656-659,共4页Journal of North Sichuan Medical College

基　　金：广东省东莞市社会发展科技项目(20211800903622)。

摘　　要：目的:分析血清脂蛋白(a)[Lp(a)]、趋化因子fractalkine(CX3CL1)水平与冠心病严重程度的关系及诱发疾病的危险因素。方法:选取306例行冠状动脉造影检查的患者为研究对象,按照检查结果不同分为冠心病组(研究组,n=185)与冠状动脉造影正常组(对照组,n=121)。比较两组患者临床资料及血清Lp(a)、CX3CL1水平;比较不同冠心病严重程度者(Grace积分分为轻度、中度、重度)的血清Lp(a)、CX3CL1水平;分析Lp(a)、CX3CL1水平与Grace积分的相关性;多因素Logistic回归分析诱发冠心病的危险因素。结果:研究组体质量指数(BMI)、高血压比例、糖尿病比例及血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、Lp(a)、CX3CL1均高于对照组(P<0.05),高密度脂蛋白胆固醇(HDL-C)低于对照组(P<0.05);冠心病不同严重程度患者血清Lp(a)、CX3CL1水平比较:重度组>中度组>轻度组(P<0.05);Pearson相关分析显示,冠心病患者血清Lp(a)、CX3CL1水平均与Grace评分呈正相关(P<0.05);多因素Logistic回归分析显示,高血压、糖尿病、TC、LDL-C及Lp(a)、CX3CL1为诱发冠心病的独立危险因素,HDL-C为保护因素(P<0.05)。结论:血清Lp(a)、CX3CL1与冠心病患者病变严重程度有密切关系,且Lp(a)、CX3CL1是诱发冠心病的独立危险因素,应加以监测。Objective:To analyze the relationship between serum lipoprotein(a)Lp(a),chemokine fractalkine(CX3CL1)levels and the severity of coronary heart disease(CHD)and to analysis the risk factors for inducing disease.Methods:306 patients who underwent coronary angiography(CAG)were selected as the research subjects.According to the different examination results,they were divided into the coronary heart disease group(research group,n=185)and the normal coronary angiography group(control group,n=121).The clinical data and levels of serum Lp(a)and CX3CL1 were compared between the two groups.The levels of serum Lp(a)and CX3CL1 were compared among CHD patients with different severity(mild,moderate,severe according to Grace score).The correlation between Lp(a),CX3CL1 levels and Grace score was analyzed.The risk factors of CHD were analyzed by multivariate Logistic method.Results:The body mass index(BMI),proportions of hypertension and diabetesand serum total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),Lp(a),CX3CL1 in study group were higher than those in control group(P<0.05),while high-density lipoprotein cholesterol(HDL-C)was lower than that in control group(P<0.05).The levels of serum Lp(a)and CX3CL1 in patients with severe group were higher than those with mild and moderate CHD(P<0.05),and the moderate group was higher than the mild group(P<0.05).Pearson correlation analysis showed that levels of serum Lp(a)and CX3CL1 were positively related with Grace score in CHD patients(P<0.05).Multivariate Logistic regression analysis showed that hypertension,diabetes,TC,LDL-C,Lp(a)and CX3CL1 were independent risk factors of CHD,while HDL-C was a protective factor(P<0.05).Conclusion:Serum Lp(a)and CX3CL1 are closely related to the severity of CHD.Lp(a)and CX3CL1 are independent risk factors of CHD,which should be monitored.

关 键 词：脂蛋白(a) 趋化因子FRACTALKINE 冠心病 严重程度 危险因素 

分 类 号：R446.1[医药卫生—诊断学] R541.4[医药卫生—临床医学]