研究阿奇霉素联合苍耳子合剂对慢性鼻窦炎患儿的临床效果及鼻部症状、睡眠质量的影响  

To Study the Clinical Effect,Nasal Symptoms and Sleep Quality of Children with Chronic Treated with Azithromycin Combined with Xanthium Mixture

作　　者：吴志辉 WU Zhihui(The Third Hospital of Zhangzhou,Zhangzhou 363005,China)

机构地区：[1]漳州市第三医院,漳州363005

出　　处：《世界睡眠医学杂志》2023年第3期534-537,共4页World Journal of Sleep Medicine

摘　　要：目的:研究阿奇霉素联合苍耳子合剂对慢性鼻窦炎患儿的临床效果及鼻部症状、睡眠质量的影响。方法:选取2020年9月至2022年8月漳州市第三医院儿科收治慢性鼻窦炎患儿100例作为研究对象,按照随机数字表法分为观察组和对照组,每组50例。对照组给予药物阿奇霉素治疗,观察组在对照组基础上联合苍耳子合剂治疗。观察2组患儿的临床疗效评价指标,采用鼻腔鼻窦结局检测-20评估量表对患儿鼻部临床症状表现、睡眠障碍、相关症状以及情感结局4个不同维度进行评估,采用酶联免疫吸附测定(ELISE)方法检测患儿治疗前后血清超敏C-反应蛋白(hs-CRP)、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)指标水平定。结果:治疗8个疗程后,观察组临床总有效率显著高于对照组,2组患儿鼻部症状评分、睡眠障碍评分、相关症状评分与情感结局评分皆明显降低,且观察组显著低于对照组,2组比较差异有统计学意义(P<0.05);观察组患儿经8个疗程后,血清hs-CRP水平均较对照组降低,2组比较差异有统计学意义(P<0.05)。结论:在儿童慢性鼻窦炎疾病临床治疗过程中,采取药物阿奇霉素、苍耳子合剂联合治疗方式,不仅可明显抑制炎性因子,改善鼻部症状,提升睡眠质量,还能获得满意的临床疗效,值得推广应用。Objective:To study the clinical effect,nasal symptoms and sleep quality of children with chronic sinusitis treated with azithromycin combined with Xanthium mixture.Methods:A total of 100 children with chronic sinusitis admitted to the Department of Pediatrics of Zhangzhou Third Hospital from September 2020 to August 2022 were selected as research objects and divided into observation group and control group according to the random number table method,with 50 cases in each group.The control group was treated with azithromycin,and the observation group was treated with Xanthium mixture on the basis of control group.Clinical efficacy evaluation indexes of the two groups of children were observed,and four different dimensions of nasal clinical symptoms,sleep disorders,related symptoms and emotional outcomes were evaluated by the nasal sinus outcome test-20 evaluation scale.The serum levels of hypersensitive C-reactive protein(hs-CRP),interleukin-2(IL-2)and interleukin-6(IL-6)before and after treatment were detected by enzyme-linked immunosorbent assay(ELISE).Results:After 8 courses of treatment,the total clinical effective rate of the observation group was significantly higher than that of the control group,and the scores of nasal symptoms,sleep disorders,related symptoms and emotional outcome were significantly decreased in 2 groups,and the observation group was significantly lower than the control group,the difference between the 2 groups was statistically significant(P s<0.05).After 8 courses of treatment,the serum hs-CRP level of the observation group was lower than the control group,and the difference between the 2 groups was statistically significant(P<0.05).Conclusion:In the clinical treatment of chronic sinusitis in children,the combination treatment of azithromycin and Xanthium mixture not only can significantly inhibit inflammatory factors,improve nasal symptoms,improve sleep quality,but also obtain satisfactory clinical efficacy,worthy of popularization and application.

关 键 词：儿童慢性鼻窦炎 苍耳子合剂 阿奇霉素 鼻部症状 炎性因子 

分 类 号：R765.21[医药卫生—耳鼻咽喉科] R338.63[医药卫生—临床医学]