观察布地奈德联合复方异丙托溴铵压缩雾化吸入对慢阻肺急性发作患者的疗效及睡眠质量的影响  

To Observe the Effect of Budesonide Combined with Compound Ipratropium Bromide Compressed Atomized Inhalation on Patients with Acute COPD and Sleep Quality

作　　者：谢清 XIE Qing(Pingtan Comprehensive Experimental Area Hospital,Pingtan 350400,China)

机构地区：[1]平潭综合实验区医院,平潭350400

出　　处：《世界睡眠医学杂志》2023年第3期660-663,共4页World Journal of Sleep Medicine

摘　　要：目的:观察布地奈德联合复方异丙托溴铵压缩雾化吸入对慢阻肺急性发作患者的疗效及睡眠质量的影响。方法:选取2020年1月至2022年12月平潭综合实验区医院急诊科收治的慢阻肺急性发作期患者60例作为研究对象,按照单双号法随机分为观察组和对照组,每组30例。对照组给予常规治疗,观察组在常规治疗基础上实施布地奈德联合复方异丙托溴铵压缩雾化吸入治疗。采用匹兹堡睡眠指数量表(PSQI)比较2组患者干预前后睡眠质量的变化,比较2组患者的临床治疗效果,比较2组患者的肺功能指标,包括将第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、峰值呼气流速(PEF)以及FEV1/FVC等,比较2组患者的生命体征,包括干预前后RR、HR、舒张压以及收缩压水平,比较2组患者的血气指标,包括二氧化碳分压(PaCO_(2))、血氧分压(PaO_(2))以及pH值,同时比较2组患者不良反应发生情况。结果:干预后,观察组临床治疗总有效率显著高于对照组,观察组患者的各项肺功能指标改善情况均优于对照组,观察组患者的生命体征稳定情况显著优于对照组,观察组患者的各项血气指标改善情况优于对照组,观察组不良反应发生率显著低于对照组,PSQI评分显著低于对照组,2组比较差异有统计学意义(P<0.05)。结论:对于慢阻肺急性发作期患者,应在常规治疗基础上增加布地奈德联合复方异丙托溴铵压缩雾化吸入治疗,这种治疗方式可以有效改善患者的血气指标以及肺功能指标,稳定患者生命体征,对提升患者的临床治疗效果以及睡眠质量具有积极作用,值得临床推广使用。Objective:To observe the effect of budesonide combined with compound ipratropium bromide compressed atomized inhalation on the efficacy and sleep quality of patients with acute COPD.Methods:A total of 60 patients with acute COPD attack admitted to the emergency department of Pingtan Comprehensive Experimental Area Hospital from January 2020 to December 2022 were selected as research objects,and were randomly divided into observation group and control group according to odd-even number method,with 30 cases in each group.The control group received conventional treatment,and the observation group received budesonide combined with compound ipratropium bromide compressed atomization inhalation therapy on the basis of conventional treatment.Pittsburgh Sleep Index Scale(PSQI)was used to compare the changes of sleep quality before and after intervention between 2 groups,the clinical treatment effects between 2 groups were compared,and the lung function indexes including forced expiratory volume in the first second(FEV 1),forced vital capacity(FVC),peak expiratory flow rate(PEF)and FEV 1/FVC,etc were compared,the vital signs,including RR,HR,diastolic blood pressure and systolic blood pressure before and after intervention,blood gas indexes,including partial carbon dioxide pressure(PaCO 2),partial oxygen pressure(PaO 2)and pH,and the incidence of adverse reactions were compared as well.Results:After intervention,the total effective rate of clinical treatment in the observation group was significantly higher than that of the control group,the improvement of lung function indexes in the observation group was better than the control group,the stability of vital signs in the observation group was significantly better than the control group,the improvement of blood gas indexes in the observation group was better than the control group,and the incidence of adverse reactions、PSQI score in the observation group was significantly lower than that of the control group,and the difference between the two groups was statistically sign

关 键 词：布地奈德 复方异丙托溴铵 压缩雾化吸入 慢阻肺急性发作 疗效 睡眠质量 

分 类 号：R563[医药卫生—呼吸系统] R338.63[医药卫生—内科学]