奥美拉唑三联疗法在儿童Hp感染性消化性溃疡中的应用效果分析  

Curative Effect of Omeprazole in the Treatment of Hp⁃positive Peptic Ulcer in Children

作　　者：阮景艳 田园园 和娟娟 RUAN Jingyan;TIAN Yuanyuan;HE Juanjuan(Department of Pediatrics,Suixian Maternity andChild Health Care Hospital,Shangqiu,Henan 476900,China;Department of Gynecology,Suixian Maternity andChild Health Care Hospital,Shangqiu,Henan 476900,China)

机构地区：[1]睢县妇幼保健院儿科,河南商丘476900 [2]睢县妇幼保健院妇科,河南商丘476900

出　　处：《中国烧伤创疡杂志》2023年第3期236-239,共4页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的分析奥美拉唑三联疗法在儿童幽门螺杆菌(Hp)感染性消化性溃疡中的应用效果。方法选取2018年1月至2020年6月睢县妇幼保健院收治的123例Hp感染性消化性溃疡患儿作为研究对象,按照随机数表法将其随机分为观察组(62例)和对照组(61例),观察组患儿采用奥美拉唑+阿莫西林+克拉霉素治疗,对照组患儿采用西咪替丁+阿莫西林+克拉霉素治疗,对比观察两组患儿临床疗效、Hp清除率、血清炎症因子水平以及不良反应发生情况。结果治疗4周后,观察组患儿中显效48例、有效12例、无效2例,明显优于对照组患儿的显效35例、有效16例、无效10例(Z=-2.595,P=0.009);观察组患儿Hp清除率为93.55%,明显高于对照组患儿的Hp清除率75.41%(χ^(2)=7.745,P=0.005);观察组患儿血清白细胞介素⁃6(IL⁃6)、C反应蛋白(CRP)和肿瘤坏死因子⁃α(TNF⁃α)水平均明显低于对照组(t=8.510、13.467、5.199,P均<0.001)。治疗期间,观察组患儿不良反应发生率为8.06%,与对照组患儿的不良反应发生率6.56%无明显差异(χ^(2)=0.103,P=0.748)。结论以奥美拉唑为主的三联疗法更能提高儿童Hp感染性消化性溃疡的Hp清除率,降低炎症反应程度,提高治疗效果。Objective To analyze the curative effect of Omeprazole in the treatment of Hp⁃positive peptic ulcer in children patients.Methods 123 children with Hp⁃positive peptic ulcer admitted into Suixian Maternity and Child Health Care Hospital between January 2018 and June 2020 were enrolled as research subjects,and then divided into study group(n=62)and control group(n=61)using the random number table.Patients in the study group were treated with Ome⁃prazole+Amoxicillin+Clarithromycin,while patients were treated with Cimetidine+Amoxicillin+Clarithromycin in the control group.The curative effect,Hp eradication rate,levels of inflammatory factors and occurrence of adverse reactions were compared between the two groups.Results After 4 weeks of treatment,the curative effect was evaluated as markedly effective in 48 cases,effective in 12 cases and ineffective in 2 cases in the study group,which was obviously superior to that in the control group(Z=-2.595,P=0.009)⁃markedly effective in 35 cases,effective in 16 cases and ineffective in 10 cases.The Hp eradication rate of patients in the study group was 93.55%,being obviously higher than the corresponding 75.41%in the control group(χ^(2)=7.745,P=0.005).The levels of interleukin⁃6(IL⁃6),C⁃reactive protein(CRP)and tumor necrosis factor⁃α(TNF⁃α)of patients in the study group were all markedly lower compared with the control group(t=8.510,13.467 and 5.199,all P<0.001).During the course of treatment,the incidence of adverse reactions was 8.06%in the study group,which showed no significant difference compared with the corresponding 6.56%in the control group(χ^(2)=0.103,P=0.748).Conclusion The Omeprazole⁃based triple therapy is more favorable for the elevation of Hp eradication rate in children patients with Hp⁃positive peptic ulcer,the decrease of inflammatory responses,and the improvement of curative effect.

关 键 词：奥美拉唑 儿童 消化性溃疡 幽门螺杆菌 炎症因子 

分 类 号：R725.7[医药卫生—儿科]