肾功能亢进ICU患者的抗菌药物给药方案调整策略研究进展  

Optimization strategy of antibiotic dosing regimen in intensive care unit patients with augmented renal clearance

作　　者：党子龙[1,2] 刘海洋 张扬帆 刘金凤 张天为 李斌 郭鸿[3] 成文媛[1] 许晓辉[4] 李一乐 魏玉辉 武新安[1,2,6] DANG Zilong;LIU Haiyang;ZHANG Yangfan;LIU Jinfeng;ZHANG Tianwei;LI Bin;GUO Hong;CHENG Wenyuan;XU Xiaohui;LI Yile;WEI Yuhui;WU Xin'an(Department of Pharmacy,The First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China;The First School of Clinical Medicine,Lanzhou University,Lanzhou 730000,Gansu,China;Department of Critical Care Medicine,The First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China;Lanzhou Institute for Food and Drug Control,Lanzhou 730050,Gansu,China;School of Pharmacy,Lanzhou University,Lanzhou 730000,China;Engineering Research Centre of Prevention and Control for Clinical Medication Risk,Gansu Province,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州大学第一医院药剂科,甘肃兰州730000 [2]兰州大学第一临床医学院,甘肃兰州730000 [3]兰州大学第一医院重症医学科,甘肃兰州730000 [4]兰州市食品药品检验检测研究院,甘肃兰州730050 [5]兰州大学药学院,甘肃兰州730000 [6]甘肃省临床用药风险防控工程研究中心,甘肃兰州730000

出　　处：《中国临床药理学与治疗学》2023年第5期561-571,共11页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金项目(82260730,U21A20424,81960680);甘肃省自然科学基金青年基金项目(20JR10RA707);甘肃省兰州市城关区科技局科技计划项目(2020SHFZ0033);兰州大学医学教育创新发展项目(lzuyxcx-2022-194);兰州大学大学生创新创业计划项目(202010730214,20190060141,20210060148,20220060079,20220060046);甘肃省高等学校创新能力提升项目(2019B-002);兰州大学第一医院院内基金(ldyyyn2018-74)。

摘　　要：重症监护患者(ICU)肾功能亢进(augmented renal clearance,ARC)发生率高,且由于此类患者常合并感染,ARC的发生会使其对抗菌药物的清除率显著增加,导致常规剂量不易达到有效治疗浓度,影响患者抗感染治疗效果及预后。由此可见,为ARC的ICU患者制定合理给药方案非常重要。遗憾的是,国内鲜有针对此类患者抗菌药物给药方案调整策略的报道。因此,为了使医务人员对针对此类患者进行抗菌药物剂量调整时有据可依,本文对国内外文献进行综述,以供临床参考。The incidence of augmented renal clearance(ARC)in intensive care patients(ICU)is exceptionally high,and these patients are often co-morbid with infection.The occurrence of ARC will significantly increase the clearance rate of antibiot-ics,making it difficult for conventional doses to reach effective therapeutic concentrations and af-fect the patient's anti-infective treatment effect and prognosis.It can be seen that it is crucial to for-mulate a reasonable dosing regimen for ICU pa-tients with ARC.Regrettably,few reports in China about the adjustment strategy of antibiotic dosing regimens for ARC patients.Therefore,this article reviews the domestic and foreign literature for ref-erence to provide evidence for medical personnel to adjust the dose of antibacterial drugs for such patients.

关 键 词：肾功能亢进 抗菌药物 重症监护患者 调整策略 

分 类 号：R941.427[医药卫生—药剂学]