中药注射液防治抗肿瘤药物心脏毒性的效应和机制  

Effects and mechanism of traditional Chinese medicine injection in prevention and treatment of cardiotoxicity induced by antineoplastic drugs

作　　者：李艳阳[1,2,3,4] 王云姣 吕仕超 LI Yanyang;WANG Yunjiao;LV Shichao(Department of Integrated Traditional&Western Medicine,Tianjin Medical University Cancer Institute and Hospital,Tianjin 300060,China;National Clinical Research Center for Cancer,Tianjin 300060,China;Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China;Tianjin's Clinical Research Center for Cancer,Tianjin 300060,China;Department of Geratology,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China)

机构地区：[1]天津医科大学肿瘤医院中西医结合科,天津300060 [2]国家肿瘤临床医学研究中心,天津300060 [3]天津市“肿瘤防治”重点实验室,天津300060 [4]天津市恶性肿瘤临床医学研究中心,天津300060 [5]天津中医药大学第一附属医院老年病科,天津300381

出　　处：《中国临床药理学与治疗学》2023年第5期572-577,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(81904118);中华中医药学会青年人才托举工程(CACM-2018-QNRC2-B04)。

摘　　要：基于文献梳理防治抗肿瘤药物心脏毒性的中药注射液,主要为生脉注射液、参麦注射液、参附注射液、参芪扶正注射液、康艾注射液、黄芪注射液、心脉隆注射液、丹红注射液、丹参注射液、红花注射液、复方苦参注射液、华蟾素注射液、银杏达莫注射液等,其效应机制主要有抗氧化应激、抑制细胞凋亡、减轻炎症反应等,为中医药防治抗肿瘤药物心脏毒性提供依据。Traditional Chinese medicine injec-tions for the prevention and treatment of cardio-toxicity of antineoplastic drugs was summarized,in-cluding Shengmai injection,Shenmai injection,Shenfu injection,Shenqi Fuzheng injection,Kangai injection,Huangqi injection,Xinmailong injection,Danhong injection,Danshen injection,Honghua in-jection,Kushen injection,Cinobufacin injection and Yinxingdamo injection.The mechanism of effect mainly includes inhibition of lipid peroxidation,re-duction of calcium overload and anti-cardiomyo-cyte apoptosis,which provides the basis for the prevention and treatment of cardiotoxicity of anti-tumor drugs by traditional Chinese medicine.

关 键 词：恶性肿瘤 肿瘤心脏病学 心脏毒性 中药注射液 

分 类 号：R285.6[医药卫生—中药学] R979.1[医药卫生—中医学]