含非挥发性盐样品的质谱分析技术进展  

Research progress in mass spectrometry analysis for samples containing non-volatile salts

作　　者：陈维伟 何誉文 褚冯键 韦玮 何佺 王文海[3] 冯鸿儒 潘远江[1] CHEN Weiwei;HE Yuwen;CHU Fengjian;WEI Wei;HE Quan;WANG Wenhai;FENG Hongru;PAN Yuanjiang(Department of Chemistry,Zhejiang University,Hangzhou 310027,China;Key Laboratory of Advanced Micro/Nano Electronic Devices and Smart Systems of Zhejiang,College of Information Science and Electronic Engineering,Zhejiang University,Hangzhou 310027,China;The Plaform of NGICS,Zhejiang University,Hangzhou 310027,China)

机构地区：[1]浙江大学化学系,杭州310027 [2]先进微纳电子器件与智能系统浙江省重点实验室,浙江大学信息科学与电子工程学院,杭州310027 [3]浙江大学NGICS大平台,杭州310027

出　　处：《分析试验室》2023年第5期696-710,共15页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金(21906137);浙江省自然科学基金(LGC21B050008)资助。

摘　　要：质谱直接分析含有非挥发性盐的样品仍有一定挑战。一方面,非挥发性盐易于结晶,会严重污染和堵塞质谱的传输系统,如毛细管、离子传输管、采样锥等,对分析结果带来影响并对质谱造成伤害。另一方面,非挥发性盐会带来离子抑制现象,质谱图会被大量的盐簇峰占据,显著降低待测物信号并干扰电荷分布状态的分辨。近年来已发展出许多针对含有非挥发性盐样品的质谱分析方法。本文综述了目前的研究现状和进展,重点介绍了常规离子源改造和常压离子源在含盐样品分析中的作用,并简要总结了一些预处理技术。最后对含非挥发性盐样品的质谱分析的发展趋势做出预测与展望。It's still a challenge for mass spectrometers(MS)to analyze samples in non-volatile salts systems.On the one hand,non-volatile salts are easy to crystallize,which will seriously contaminate and clog the transmission system of mass spectrometry,such as capillaries,ion transfer tubes,sampling cones,etc.,thus the analysis results can be affected and the MS can be damaged.On the other hand,non-volatile salts always bring ion suppression,which significantly reduces the signal intensity of the analytes.At the same time,the mass spectrum will be dominated by a large number of salt cluster peaks,interfering with the discrimination of charge state.Recently,different methods have been developed to solve above two problems.This article reviewed the present research progress of mass spectrometry analysis for salt-containing samples,focusing on the role of conventional ion source modification and ambientionization mass spectrometry in the analysis of salt-containing samples.Pretreatment methods were also summarized briefly.Finally,the development tendency of mass spectrometry analysis for salt containing samples is predicted and prospected.

关 键 词：质谱分析 非挥发性盐 脱盐 

分 类 号：O657.63[理学—分析化学] Q5-33[理学—化学]