CT小肠造影诊断Cronkhite-Canada综合征临床案例分析  

The Diagnosis of Cronkhite-Canada Syndrome with CT Enterography: A Clinical Case Analysis

作　　者：赵雪松[1] 缪飞[1] 孙菁[2] 董屹寒 张欢[1] 严福华[1] 丁蓓[1] ZHAO Xuesong;MIAO Fei;SUN Jing;DONG Yihan;ZHANG Huan;YAN Fuhua;DING Bei(Department of Radiology,Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;Department of Gastroenterology,Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;Department of Pathology,Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院放射科,上海200025 [2]上海交通大学医学院附属瑞金医院消化科,上海200025 [3]上海交通大学医学院附属瑞金医院病理科,上海200025

出　　处：《CT理论与应用研究（中英文）》2023年第2期263-270,共8页Computerized Tomography Theory and Applications

摘　　要：Cronkhite-Canada综合征(CCS)是一组以胃肠道弥漫性息肉和外胚层变化为特征的综合征,其临床表现主要为慢性腹泻和吸收不良,由于发病率罕见,早期发现和诊断对医生来说是一个挑战。本文报告1例CCS病例,58岁男性,临床表现为慢性水样腹泻、便血、体重减轻和皮肤变化,包括指甲营养不良和色素沉着;实验室检查结果提示贫血和低蛋白血症;CT小肠造影检查发现全消化道黏膜息肉样增生,高度怀疑CCS,随后行内镜检查证实了该诊断。患者经治疗后,症状明显好转,在近1年的随访中,CT小肠造影和内镜检查均提示明显缓解。本文对该疾病进行文献综述,旨在总结其CT小肠造影表现,以提高临床医生对本病的认识,为CCS的早期诊断提供一定的思路。Cronkhite-Canada syndrome(CCS) is a rare cause of chronic diarrhea and malabsorption where patients develop multiple polyps throughout the gastrointestinal(GI) tract, accompanied by ectodermal changes. Due to its rarity, its early detection and diagnosis can be challenging for physicians. This case report described a 58-year-old male patient with CCS who presented with chronic watery diarrhea, hematochezia, weight loss, and skin changes including nail dystrophy and hyperpigmentation. Laboratory results showed anemia and hypoalbuminemia. He underwent CT enterography(CTE) which identified diffuse edematous polyposis in the GI tract. The CTE results were highly suspicious of CCS and a subsequent endoscopic examination confirmed the diagnosis. The patient received supportive treatment which improved his symptoms. Based on CTE and endoscopy at 1-year follow-up, the patient was deemed to be in remission. We included a literature review of CCS. The case report aimed to improve the understanding of CCS and explored the key CTE features relevant to its early diagnosis.

关 键 词：CT小肠造影 息肉-色素沉着-脱发-指(趾)甲营养不良综合征 诊断 

分 类 号：R814[医药卫生—影像医学与核医学]