天然生物材料促进创面修复的研究进展  

Research advances of natural biomaterials in promoting wound repair

作　　者：高仪轩 王凌峰 巴特[1] 邹晓防 曹胜军[1] 李俊亮 李芳 周彪[1] Gao Yixuan;Wang Lingfeng;Ba Te;Zou Xiaofang;Cao Shengjun;Li Junliang;Li Fang;Zhou Biao(Department of Burns,Inner Mongolia Baotou Steel Hospital,Baotou 014010,China;Burn Medical Institute of Inner Mongolia,Baotou 014010,China;Department of Burns and Plastic Surgery,Air Force Specialty Medical Center,Air Force Medical University,Beijing)

机构地区：[1]内蒙古包钢医院烧伤外科,包头014010 [2]内蒙古烧伤医学研究所,包头014010 [3]空军军医大学空军特色医学中心烧伤整形外科,北京100142

出　　处：《中华烧伤与创面修复杂志》2023年第5期481-486,共6页Chinese Journal of Burns And Wounds

基　　金：国家自然科学基金面上项目(82060348);内蒙古自治区自然科学基金(2020MS08022);内蒙古自治区科技计划(2020GG0214);内蒙古自治区科技创新引导项目(CXYD2020BT03);包头市卫生健康委科技计划(wsjkwkj048);空军特色医学中心面上项目(2021LC020)。

摘　　要：急慢性创面严重威胁患者的生命健康和生活质量,因此创面修复是近年来国内外学者研究的热点问题。随着材料学与组织工程的发展,越来越多由天然成分制备的生物材料被用于创面修复的基础研究和临床治疗,此类材料可作为创面组织再生的模板,诱导自体细胞黏附、迁移,促进细胞外基质沉积,具有广阔的临床应用前景。该文对创面修复领域中目前研究热门的天然生物材料的特点及其应用进展作一综述,旨在为新型创面敷料及组织工程皮肤研发提供思路。Acute and chronic wounds seriously threaten patients'life health and quality of life,therefore,wound repair has become a hot topic of research for scholars at home and abroad in recent years.With the development of material science and tissue engineering,more and more biomaterials prepared from natural ingredients were used in basic research and clinical treatment of wound repair.Such biomaterials can be used as templates for wound tissue regeneration to induce autologous cell adhesion and migration,and promote the deposition of extracellular matrix,which have broad clinical application prospects.This paper reviews the characteristics and application advance of natural biomaterials which are popular in the field of wound repair,aiming to provide ideas for the research and development of new wound dressing and tissue engineering skin.

关 键 词：生物相容性材料 纤维素 壳聚糖 丝素蛋白 创面修复 脱细胞真皮基质 脱细胞羊膜 

分 类 号：R318.08[医药卫生—生物医学工程] R641[医药卫生—基础医学]