口腔黏膜干细胞促进创面愈合的机制研究进展  

Research advances on the mechanism of oral mucosal stem cells in promoting wound healing

作　　者：魏志茹[1] 董炎 李广帅[1] 刘林嶓[1] Wei Zhiru;Dong Yan;Li Guangshuai;Liu Linbo(Department of Plastic Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of General,Visceral and Transplantation Surgery,University Hospital Heidelberg,Heidelberg 69120,Germany)

机构地区：[1]郑州大学第一附属医院整形外科,郑州450052 [2]Department of General,Visceral and Transplantation Surgery,University Hospital Heidelberg,Heidelberg 69120,Germany

出　　处：《中华烧伤与创面修复杂志》2023年第5期496-500,共5页Chinese Journal of Burns And Wounds

基　　金：河南省2022年科技发展计划项目(222102310188)。

摘　　要：创面愈合是需要多种细胞及细胞因子参与的复杂过程。在创面愈合过程中,任何一个环节出现异常,都可能导致创面发展成为慢性难愈合创面。研究证实多种干细胞可促进创面愈合,但部分干细胞因存在提取困难、易凋亡、伦理及法律等问题,临床应用受限。而口腔黏膜干细胞可规避上述问题,这类干细胞具有胚胎干细胞特性、免疫调节能力,而且同质性强,在口腔创面无瘢痕愈合过程中发挥重要作用,成为促进创面愈合及减少瘢痕形成的研究热点。该文综述口腔黏膜干细胞促进创面愈合的机制研究、临床应用前景及目前存在的问题。Wound healing is a complex process that requires the participation of multiple cells and cytokines.During the process of wound healing,abnormality in any stage of the process may lead to the development of a chronic refractory wound.Research has confirmed that various stem cells can promote wound healing,but some stem cells are limited in clinical application due to difficulties in isolation,susceptibility to apoptosis,ethical and legal issues.Oral mucosal stem cells(OMSCs)can avoid the above problems.This type of stem cells has the characteristics of embryonic stem cells,immune regulatory ability,and strong homogeneity.It plays an important role in the process of scarless oral wound healing,and has become a research hotspot in promoting wound healing and reducing scar formation.This article reviews the research on the mechanism,clinical application prospects,and current problems of OMSCs in promoting wound healing.

关 键 词：伤口愈合 细胞因子类 口腔黏膜干细胞 多能性 

分 类 号：R641[医药卫生—外科学]