特征肠道菌群在中医方证中的研究现状及意义  

Current status and significance of research on intestinal characteristic microbiota in TCM prescriptions

作　　者：于子真 吴仪 谭周进[1] YU Zi-zhen;WU Yi;TAN Zhou-jin(Hu′nan University of Chinese Medicine,Changsha,Hu′nan 410208,China)

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《中国微生态学杂志》2023年第4期489-493,共5页Chinese Journal of Microecology

基　　金：国家自然科学基金(81874460);湖南省自然科学基金(2020JJ4468)。

摘　　要：基于微生态学与中医学的一致性,以及中医证型及方剂治疗与肠道菌群密切相关,进一步研究特定肠道菌群与中医方证的关系对中医药现代化具有重要意义。本文论述了肠道菌群与疾病、中医证型及方剂疗效的相关性研究现状,认为同一疾病不同的中医证型具有不同的肠道菌群变化特征,明显富集或降低的肠道菌群与证型密切相关,甚至有望成为诊断的生物标记物。方剂能调控特定的肠道菌群,肠道菌群在一定程度上能反映方剂的疗效,借助肠道菌群的特征变化理解方剂疗效机制,有望辅助方剂的临床运用与选择。因而,深化肠道菌群在中医方证的研究是促进中医药现代化的新兴发展方向。Based on the consistency between microecology and TCM,as well as the close relationship of TCM syndrome types and formulae treatment with intestinal microbiota,it is of great significance to further study the relationship between specific intestinal microbiota and formulae and syndrome in terms of the modernization of TCM.This paper discusses the status of research on the correlation of TCM syndrome types and formulae with intestinal microbiota.Different TCM syndrome types of the same disease have different characteristics of intestinal microbiota.The obvious enrichment or reduction of intestinal microbiota is closely related to syndrome types,and may even become diagnostic biomarkers.Formulae can regulate specific intestinal microbiota,which can reflect the efficacy of TCM formulae to a certain extent.The characteristic changes of intestinal microbiota are helpful to understand the TCM mechanisms of formulae,and it is very expected to assist the clinical application and selection of formulae.Therefore,deepening the study on intestinal microbiota in terms of TCM syndrome types and formulae will be a new development direction to promote the modernization of TCM.

关 键 词：肠道菌群 中医证型 方剂 方证相应学说 中医药现代化 

分 类 号：R285[医药卫生—中药学]