心房颤动病人血清SLC7A11、FGF23水平检测及临床意义  

Detection and clinical significance of serum SLC7A11 and FGF23 levels in patients with atrial fibrillation

作　　者：刘薇薇 卢园园 冷俊杰 高崎 康品方[1,2] 张宁汝[1] LIU Wei-wei;LU Yuan-yuan;LENG Jun-jie;GAO Qi;KANG Pin-fang;ZHANG Ning-ru(Department of Cardiology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004;Heart and Cerebrovascular Disease Research Center,Bengbu Medical College,Bengbu Anhui 233030,China)

机构地区：[1]蚌埠医学院第一附属医院心血管内科,安徽蚌埠233004 [2]蚌埠医学院心脑血管病研究中心,安徽蚌埠233030

出　　处：《蚌埠医学院学报》2023年第5期573-576,581,共5页Journal of Bengbu Medical College

基　　金：国家自然科学基金资助项目(81970313);安徽省重点研究和开发计划(1804h08020246);优秀青年科学基金项目(2019byyfyyq)。

摘　　要：目的:检测心房颤动(AF)病人与窦性心律者血清溶质载体家族7成员11(SLC7A11)、血清成纤维细胞生长因子23(FGF23)的水平,分析二者与AF之间的相关性及临床意义。方法:选取住院的AF病人118例作为观察组,根据相关指南分为阵发性AF组67例和非阵发性AF组51例。对照组选取窦性心律健康者96名。选择酶联吸附免疫实验法(ELISA)测出血清中SLC7A11、FGF23浓度;比较3组病人的临床资料及血清学指标,利用Pearson相关性分析血清SLC7A11、FGF23水平与超声心动图中左房内径(LAD)、左室舒张内径(LVD)、左心室射血分数(LVEF)和左心室缩短分数(FS)相关性。采用多元logsitic回归分析AF病人AF发生持续相关因素。结果:与对照组相比,血清SLC7A11在阵发性AF组和非阵发性AF组均下降(P<0.01),且非阵发性AF组中SLC7A11低于阵发性AF组(P<0.01),血清FGF23在阵发性AF组和非阵发性AF组均升高(P<0.01),且非阵发性AF组中FGF23高于阵发性AF组(P<0.01);Pearson相关性分析显示,LAD与血清SLC7A11呈负相关关系(r=-0.534,P<0.01),与血清FGF23呈正相关关系(r=0.532,P<0.01)。多元logsitic回归分析结果显示,SLC7A11是AF独立的保护因素(OR=0.231,P<0.01),而FGF23是独立危险因素(OR=1.097,P<0.01)。结论:SLC7A11、FGF23可能与AF的发病、进展有关。Objective:To detect the levels of serum solute carrier family 7 member 11(SLC7A11)and serum fibroblast growth factor 23(FGF23)in patients with atrial fibrillation(AF)and sinus rhythm,and analyze the correlation between them and AF and their clinical significance.Methods:A total of 120 AF patients who were hospitalized were selected as observation group.According to relevant guidelines,they were divided into paroxysmal AF group(70 cases)and non-paroxysmal AF group(50 cases).In the control g roup,96 healthy patients with sinus rhythm were selected.The concentrations of SLC7A11 and FGF23 in serum were measured by enzyme-linked immunosorbent assay(ELISA).The clinical data and serological indexes of the three groups were compared,and the correlation between serum SLC7A11 and FGF23 levels and left atrial diameter(LAD),left ventricular diastolic diameter(LVD),left ventricular ejection fraction(LVEF)and left ventricular shortening fraction(FS)in echocardiography was analyzed by Pearson correlation[12]ZHU HT,CHEN H,DING DG,et al.Overexpression of PIK3R1 promotes bone formation by regulating osteoblast differentiation and osteoclast formation analysis.Multivariate logistic regression was used to analyze the factors related to the occurrence and persistence of AF in patients with AF.Results:Compared with control group,serum SLC7A11 was decreased in paroxysmal AF group and in non-paroxysmal AF group(P<0.01),and SLC7A11 in non-paroxysmal AF group was lower than that of paroxysmal AF group(P<0.01);serum FGF23 was increased in paroxysmal AF group and in non-paroxysmal AF group(P<0.01),and FGF23 in non-paroxysmal AF group was higher than that of paroxysmal AF group(P<0.01).Pearson correlation analysis showed that LAD was negatively correlated with serum SLC7A11(r=0.534,P<0.01),and positively correlated with serum FGF23(r=0.532,P<0.01).Multiple logistic regression analysis results showed that SLC7A11 was an independent protective factor for AF(OR=0.231,P<0.01),while FGF23 was an independent risk factor(OR=1.097,P<0.01).Conclusion

关 键 词：心房颤动 血清溶质载体家族7成员11 血清成纤维细胞生长因子23 

分 类 号：R541.75[医药卫生—心血管疾病]