非瓣膜性房颤病人血清CRP、RDW和NLR的变化及其临床意义  

Changes of serum level of C-reactive protein,red blood cell distribution width and neutrophil-to-lymphocyte ratio in patients with non-valvular atrial fibrillation and their clinical significance

作　　者：李冬菊 竟雪莹 汤凤英 祖磊 胡茜 何佰生 薛鹏程 夏丽 LI Dong-ju;JING Xue-ying;TANG Feng-ying;ZU Lei;HU Qian;HE Bai-sheng;XUE Peng-cheng;XIA Li(Department of Medicine,The Third People′s Hospital of Bengbu Medical College,Bengbu Anhui 233000,China)

机构地区：[1]蚌埠医学院附属蚌埠第三人民医院内科,233000

出　　处：《蚌埠医学院学报》2023年第5期606-609,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨非瓣膜性房颤病人的血清C反应蛋白(CRP)、红细胞分布宽度水平(RDW)及中性粒/淋巴细胞百分比(NLR)的变化及其临床意义。方法:选择非瓣膜性房颤病人150例,并随机抽取同期于住院的非心房颤动病人100例作为对照组,记录2组病人姓名、年龄、合并疾病、实验室指标等,并比较2组各项指标的差异,同时将房颤组按房颤的分类标准分为阵发性房颤组50例和非阵发性房颤组(包括持续性房颤、长程持续性房颤、永久性房颤)100例。比较房颤亚组间各指标差异。结果:房颤组与对照组NLR及RDW、CRP差异具有统计学意义(P<0.01)。而房颤亚组间RDW、CRP及NLR差异具有统计学意义(P<0.05~P<0.01)。应用多变量回归分析显示,RDW、NLR可能是心房颤动发生的独立预测因素(P<0.01)。结论:CRP、RDW及NLR与非瓣膜性房颤发生密切相关,RDW、NLR可能是心房颤动发生的独立预测因素。CRP、RDW及NLR与非瓣膜性房颤的持续时间密切相关,非阵发性房颤组CRP、RDW及NLR高于阵发性房颤组。Objective:To investigate the changes of serum level of C-reactive protein(CRP),red blood cell distribution width(RDW)and neutrophil-to-lymphocyte ratio(NLR)in patients with non-valvular atrial fibrillation and its clinical significance.Methods:One hundred and fifty patients with non-valvular atrial fibrillation and 100 patients with non-atrial fibrillation at the same period were divided into the atrial fibrillation and control group,respectively.The names,ages,combined diseases,laboratory indicators in two groups were recorded,and compared between two groups.The atrial fibrillation group wsd subdivided into the paroxysmal atrial fibrillation group(50 cases)and non-paroxysmal atrial fibrillation group(100 cases,including persistent atrial fibrillation,long-term persistent atrial fibrillation and permanent atrial fibrillation)according to the classification criteria of atrial fibrillation,and the index among the subgroups of atrial fibrillation were compared.Results:The differences of the NLR,RDW and CRP in atrial fibrillation group and control group were statistically significant(P<0.01),and the differences of the ROW,CRP and NLR in subgroups of atrial fibrillation were also statistically significant(P<0.05 to P<0.01).The results of multivariate logistic regression analysis showed that the RDW and NLR might be an independent predictor of atrial fibrillation(P<0.01).Conclusions:The CRP,RDW and NLR are closely related to the occurrence of non-valvular atrial fibrillation,and the RDW and NLR may be the independent predictors of the occurrence of atrial fibrillation.The CRP,RDW and NLR are closely related to the duration of non-valvular atrial fibrillation,and the CRP,RDW and NLR in non-paroxysmal atrial fibrillation group are higher than those in paroxysmal atrial fibrillation group.

关 键 词：非瓣膜性房颤 C反应蛋白 中性粒/淋巴细胞百分比 红细胞分布宽度水平 

分 类 号：R541.7[医药卫生—心血管疾病]