糖尿病患者外周血炎症-氧化应激水平与胰岛素抵抗的相关性研究  

Correlation between serum inflammatory factors,oxidative stress and insulin resistance level in patients with diabetes mellitus

作　　者：张钢[1] 王海芳[1] ZHANG Gang;WANG Haifang(First Department of Endocrinology,Handan First Hospital,Hebei,Handan 056500,China)

机构地区：[1]河北省邯郸市第一医院内分泌一科,056500

出　　处：《河北医药》2023年第7期1050-1053,共4页Hebei Medical Journal

摘　　要：目的分析糖尿病(DM)患者氧化应激因子、血清炎性因子与胰岛素抵抗的相关性。方法选取内分泌科2020年2月至2022年2月收治的50例DM患者为观察组,同期体检中心就诊的50例健康体检者作为对照组。观察组患者均给予二甲双胍、门冬胰岛素治疗,比较治疗前后外周血炎性反应指标、氧化应激指标、胰岛素抵抗指标,Spearman相关性分析外周血炎性反应指标、氧化应激指标与胰岛素抵抗指标的相关性。结果观察组血清hs-CRP、TNF-α、IL-6均高于对照组,观察组血清MDA均高于对照组,观察组治疗后血清TAOC、SOD均低于对照组,观察组HOMA-IR、2 hINS均高于对照组,观察组ISI低于对照组,差异均有统计学意义(P<0.05)。观察组治疗后血清hs-CRP、TNF-α、IL-6均低于治疗前,观察组治疗后血清MDA低于对照组,血清TAOC、SOD均比治疗前高,观察组治疗后HOMA-IR、2 hINS均比治疗前低,治疗后ISI比治疗前高,差异均有统计学意义(P<0.05)。HOMA-IR、2 hINS与hs-CRP、TNF-α、IL-6、MDA均呈正相关性(r>1),与TAOC、SOD均呈负相关性(r<1),ISI与hs-CRP、TNF-α、IL-6、MDA均呈负相关性(r<1,P<0.05),与TAOC、SOD均呈正相关性(r>1,P<0.05)。结论DM患者炎性反应、氧化应激反应越严重,胰岛素抵抗程度越明显,积极给予对症治疗,可抑制炎性因子、氧化因子释放,减轻胰岛素抵抗程度。Objective To analyze the correlation between serum inflammatory factors,oxidative stress and insulin resistance level in patients with diabetes mellitus(DM).Methods From February 2020 to February 2022,50 DM patients admitted to the Endocrinology Department of our hospital were enrolled as the observation group,meanwhile,and 50 healthy subjects who visited the physical examination center were selected as the control group.The patients in the observation group were treated with metformin and insulin aspart.The level of serum inflammatory factors,oxidative stress,and insulin resistance were included as comparisons.Spearman correlation analysis was performed to analyze the correlation of serum inflammatory factors,oxidative stress and insulin resistance level.Results Before treatment,serum high-sensitivity C-reactive protein(hs-CRP),tumour necrosis factor-alpha(TNF-α),interleukin 6(IL-6),and malondialdehyde(MDA)in observation group were higher than those in control group.Serum total antioxidative capacity(TAOC),and superoxide dismutase(SOD)in observation group were lower than those in control group.The homeostasis model assessment of insulin resistance(HOMA-IR)and 2-h insulin(2hINS)in observation group were higher than those in the control group,and the international sensitivity index(ISI)was lower than that in the control group,the differences were statistically significant in above indexes(P<0.05).After treatment,serum hs-CRP,TNF-α,and IL-6 in the observation group were lower than those before treatment,the serum MDA in the observation group was lower than that in the control group,and the serum TAOC and SOD in the observation group were higher than those before treatment.HOMA-IR and 2hINS in the observation group were lower than those before treatment,and ISI was higher than that before treatment,the differences were statistically significant in above indexes(P<0.05).HOMA-IR and 2hINS were positively correlated with hs-CRP,TNF-α,IL-6,and MDA(r>1),and negatively correlated with TAOC and SOD(r<1).ISI was negative

关 键 词：糖尿病 炎性反应 氧化应激反应 胰岛素抵抗 相关性 

分 类 号：R587.1[医药卫生—内分泌]