冷敷联合布洛芬治疗哺乳期乳腺炎及对患者生活质量的影响  

Curative effect of cold compress combined with ibuprofen in the treatment of lactating mastitis and its influence on the quality of life

作　　者：步玉辉 史立波 韩晓琳 于德海 高路明 姜婷婷 田洪雨 高桂艳 BU Yuhui;SHI Libo;HAN Xiaolin(Department of Thyroid and Breast Surgery,Cangzhou People’s Hospital,Hebei,Cangzhou 061000,China)

机构地区：[1]河北省沧州市人民医院甲乳外科,061000

出　　处：《河北医药》2023年第7期1061-1064,共4页Hebei Medical Journal

摘　　要：目的探讨冷敷联合布洛芬治疗哺乳期乳腺炎及对患者生活质量的影响。方法选取2020年1月至2022年1月沧州市人民医院收治的104例哺乳期乳腺炎患者为研究对象,随机分为观察组和对照组。每组52例。对照组采用布洛芬治疗,观察组以冷敷联合布洛芬治疗。评估比较2组患者的临床疗效、炎性因子水平、母乳喂养情况、生活质量评分、不良反应发生率等指标。结果观察组治疗后总有效率为92.31%(48/52),高于对照组的76.92%(40/52)(P<0.05)。治疗后观察组患者的炎性因子包括前列腺素E2(PGE2)、单核细胞趋化蛋白4(MCP-4)、重组人趋化因子配体22(CCL22)水平均低于对照组(P<0.05)。治疗后观察组患者的母乳喂养率、母乳喂养自我效能简化量表(BSES-SF)评分均高于对照组,而观察组的回乳率低于对照组(P<0.05)。治疗后观察组患者世界卫生组织生存质量测定量表(WHOQOL-100)评分均高于对照组(P<0.05)。治疗期间观察组和对照组不良反应发生率为13.46%(7/52)、9.62%(5/52),差异无统计学意义(P>0.05)。结论冷敷治疗联合布洛芬治疗哺乳期乳腺炎的疗效显著,能够改善患者的疼痛程度,抑制炎性因子的表达,改善患者的母乳喂养情况,提高患者的生活质量,治疗安全性良好,可临床推荐。Objective To study the curative effect of cold compress combined with ibuprofen on lactating mastitis and its influence on the quality of life.Methods A total of 104 patients with lactation mastitis treated in Cangzhou people’s Hospital from January 2020 to January 2022 were randomly divided into observation group and control group,with 52 cases in each group.Patients in the control group were treated with ibuprofen,and those in the observation group were treated with cold compress combined with ibuprofen.The clinical efficacy,inflammatory factor levels,breastfeeding condition,quality of life,and incidence of adverse events were compared between the two groups.Results The overall efficacy rate was significantly higher in the observation group than that of control group(92.31%[48/52]vs 76.92%[40/52];P<0.05).After treatment,inflammatory factors levels of prostaglandin E2(PGE2),monocyte chemoattractant protein 4(MCP-4)and recombinant human chemokine ligand 22(CCL22)in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the breastfeeding rate and the score of the breastfeeding self-efficacy scale-short form(BSES-SF)in the observation group were significantly higher than those in the control group,while the lactation rate in the observation group was significantly lower than that in the control group(P<0.05).After treatment,the World Health Organization Quality of Life(WHOQOL-100)scale scores in the observation group were significantly higher than those in the control group(P<0.05).During the treatment period,the incidence of adverse events was comparable between observation group and control group(13.46%[7/52]vs 9.62%[5/52];P>0.05).Conclusion Cold compress therapy combined with ibuprofen is effective in the treatment of lactating mastitis.It can alleviate the pain,inhibit the expression levels of inflammatory factors,improve the breastfeeding situation and the quality of life.It is a safe treatment that can be recommended to the clinical application.

关 键 词：哺乳期 乳腺炎 布洛芬 冷敷治疗 镇痛效果 生活质量 母乳喂养 

分 类 号：R655.81[医药卫生—外科学]