麻醉与老年患者术后认知功能障碍及阿尔茨海默症相关性的研究进展  

Correlation between anesthesia with postoperative cognitive dysfunction and Alzheimer’s disease in elderly patients

作　　者：张琴[1] 郑渤 段志强[1] 温海茹 ZHANG Qin;ZHENG Bo;DUAN Zhiqiang(不详;Department of Anesthesiology,Bayannur Hospital,Inner Mongolia,Bayannur 015000,China)

机构地区：[1]内蒙古自治区巴彦淖尔市医院麻醉科,015000 [2]广州中山积水潭骨科医院麻醉科

出　　处：《河北医药》2023年第7期1086-1089,共4页Hebei Medical Journal

摘　　要：术后认知功能障碍(POCD)是老年患者较为常见的术后并发症之一,目前其发生机制尚未明确。虽然术后认知功能障碍是可逆的,但它不仅给患者的预后及康复造成了一定的影响,而且也增加了阿尔茨海默症(AD)的发生率。近年来,许多研究发现麻醉是POCD发生的一个重要因素;另外麻醉和POCD是AD发生率增加的重要因素。本文就术后POCD及AD目前可能存在的发生机制进行探讨;并对麻醉与老年患者术后POCD及AD的相关性、目前可以降低POCD和AD发生率的药物及方法等作一论述。Postoperative cognitive dysfunction(POCD)is one of the most common postoperative complications in elderly patients.Although POCD is reversible,it not only affects the prognosis and recovery,but also enhances the incidence of Alzheimer’s disease(AD).Recent studies have found that anesthesia is an important factor to increase the incidence of POCD.In addition,anesthesia and postoperative cognitive dysfunction are important factors that increase the incidence of AD.This review aims to describe the mechanism of POCD and AD,the correlation between anesthesia with POCD and AD,and therapeutic agents and approaches to lower the incidences of POCD and AD.

关 键 词：麻醉 术后认知功能障碍 阿尔茨海默症 

分 类 号：R614[医药卫生—麻醉学]