Effects of mild/asymptomatic COVID-19 on semen parameters and sex-related hormone levels in men:a systematic review and meta-analysis  

作　　者：Bang-Wei Che Pan Chen Ying Yu Wei Li Tao Huang Wen-Jun Zhang Sheng-Han Xu Jun He Miao Liu Kai-Fa Tang 

机构地区：[1]Department of Urology,The Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China

出　　处：《Asian Journal of Andrology》2023年第3期382-388,共7页亚洲男性学杂志（英文版）

基　　金：This study was supported by the Science and Technology Fund Project of Guizhou Health Commission(gzwkj2021-211).

摘　　要：Coronavirus disease 2019(COVID-19)has yet to be proven to alter male reproductive function,particularly in the majority of mild/asymptomatic patients.The purpose of this study was to explore whether mild/asymptomatic COVID-19 affects semen quality and sex-related hormone levels.To find suitable comparative studies,a systematic review and meta-analysis was done up to January 22,2022,by using multiple databases(Web of Science,PubMed,and Embase).Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines were used to identify and choose the studies.Meta-analysis was used to examine the semen parameters and sex-related hormones of mild/asymptomatic COVID-19 patients before and after infection.The effects of semen collection time,fever,and intensity of verification on semen following infection were also investigated.A total of 13 studies(n=770)were included in the analysis,including three case-control studies,six pre-post studies,and four single-arm studies.A meta-analysis of five pre-post studies showed that after infection with COVID-19,sperm concentration(I^(2)=0;P=0.003),total sperm count(I^(2)=46.3%;P=0.043),progressive motility(I^(2)=50.0%;P<0.001),total sperm motility(I^(2)=76.1%;P=0.047),and normal sperm morphology(I^(2)=0;P=0.001)decreased.Simultaneously,a systematic review of 13 studies found a significant relationship between semen collection time after infection,inflammation severity,and semen parameter values,with fever having only bearing on semen concentration.Furthermore,there was no significant difference in sex-related hormone levels before and after infection in mild/asymptomatic patients.Mild/asymptomatic COVID-19 infection had a significant effect on semen quality in the short term.It is recommended to avoid initiating a pregnancy during this period of time.

关 键 词：coronavirus disease 2019 male infertility META-ANALYSIS semen quality severe acute respiratory syndrome coronavirus 2 

分 类 号：R563.1[医药卫生—呼吸系统]