Genetically predicted insomnia causally increases the risk of erectile dysfunction  

作　　者：Yang Xiong Fu-Xun Zhang Yang-Chang Zhang Chang-Jing Wu Feng Qin Jiu-Hong Yuan 

机构地区：[1]Andrology Laboratory,West China Hospital,Sichuan University,Chengdu 610041,China [2]Department of Urology,West China Hospital,Sichuan University,Chengdu 610041,China [3]Department of Epidemiology and Health Statistics,School of Public Health and Management,Chongqing Medical University,Chongqing 401331,China

出　　处：《Asian Journal of Andrology》2023年第3期421-425,共5页亚洲男性学杂志（英文版）

基　　金：This work was supported by the Natural Science Foundation of China(No.81871147 and No.82071639);the Sichuan Science and Technology Program(No.2022YFS0028 and No.2022YFS0134).

摘　　要：Sleep has attracted extensive attention due to its significance in health.However,its association with erectile dysfunction(ED)is insufficiently investigated.To investigate the potential causal links between sleep traits(insomnia,sleep duration,and chronotype)and ED,this study was performed.The single-nucleotide polymorphisms(SNPs)associated with insomnia,sleep duration,and chronotype were retrieved from previous genome-wide association studies(GWAS).A conventional two-sample Mendelian randomization(MR)was used to estimate the causal links between sleep traits and ED.The summary statistics of ED were from individuals of European ancestry(6175 cases vs 217630 controls).As shown by the random effect inverse-variance-weighting(IVW)estimator,genetically predicted insomnia was causally associated with a 1.15-fold risk of ED(95%confidence interval:1.07-1.23,P<0.001).Sleep duration and morningness were not causally associated with ED,as indicated by the IVW(all P>0.05).These findings were consistent with the results of sensitivity analyses.Based on genetic data,this study provides causal evidence that genetically predicted insomnia increases the risk of ED,whereas sleep duration and chronotype do not.

关 键 词：causal association CHRONOTYPE erectile dysfunction INSOMNIA Mendelian randomization sleep duration 

分 类 号：R697[医药卫生—泌尿科学]