外用康复新液联合哌拉西林钠他唑巴坦钠治疗对葡萄球菌烫伤样皮肤综合征患儿对血清炎症因子及免疫功能的影响  

Effect of external kangfuxin solution combined with piperacillin sodium and tazobactam sodium on serum inflammatory factors and immune function of staphylococcal scalded skin syndrome in children

作　　者：尚高峰 王炳征 韩伟波 李静 袁绿益 SHANG Gaofeng;WANG Bingzheng;HAN Weibo;LI Jing;YUAN Lvyi(Department of Clinical Laboratory,People′s Hospital of Wugong County,Xianyang,Shaanxi 712200,China;Department of Pediatrics,People′s Hospital of Wugong County,Xianyang,Shaanxi 712200,China;Department of Pediatrics,Xi′an International Medical Center Hospital,Xi′an,Shaanxi 710100,China;Sichuan Key Laboratory of Periplaneta Americana for Medicinal Use,Chengdu,Sichuan 610000,China)

机构地区：[1]陕西省武功县人民医院检验科,陕西咸阳712200 [2]陕西省武功县人民医院儿科,陕西咸阳712200 [3]西安国际医学中心医院小儿内科,陕西西安710100 [4]药用美洲大蠊四川省重点实验室,四川成都610000

出　　处：《检验医学与临床》2023年第11期1515-1518,共4页Laboratory Medicine and Clinic

基　　金：四川省科学技术厅研究应用成果转化示范项目(2018CC0034)。

摘　　要：目的探讨外用康复新液联合哌拉西林钠他唑巴坦钠治疗对葡萄球菌烫伤样皮肤综合征(SSSS)患儿对血清炎症因子与免疫功能的影响。方法选择2018年1月至2021年12月陕西省武功县人民医院儿科与西安国际医学中心医院小儿内科收治的SSSS住院患儿90例作为研究对象,采用随机数字表法分为治疗组和对照组,每组45例。两组患儿均给予清洁创面褶皱部糜烂皮肤及对症支持治疗。对照组给予哌拉西林钠他唑巴坦钠100 mg/(kg·d)加入0.9%氯化钠注射液中静脉滴注,3次/天,治疗7~14 d为1个疗程;治疗组在给予哌拉西林钠他唑巴坦钠治疗基础上采用消毒棉签蘸取康复新液外涂创面后暴露,4次/天,治疗7~14 d为1个疗程。比较两组患儿临床疗效、炎症因子[包括C反应蛋白(CRP)、降钙素原(PCT)和血清淀粉样蛋白A(SAA)]及免疫功能(包括CD3^(+)、CD4^(+)和CD8^(+))、不良反应发生情况等。结果治疗组患儿总有效率高于对照组,退热、皮疹消退、尼氏征转阴、治愈时间均短于对照组,差异均有统计学意义(P<0.05)。两组患儿治疗后CRP、PCT、SAA、CD8^(+)水平均比治疗前降低,CD3^(+)、CD4^(+)水平均比治疗前升高,且治疗组患儿治疗后CRP、PC T、SAA、CD8^(+)水平均低于对照组,CD3^(+)、CD4^(+)水平均高于对照组,差异均有统计学意义(P<0.05)。两组患儿不良反应发生率均较低(13.3%vs.11.1%),差异无统计学意义(P>0.05)。结论外用康复新液联合哌拉西林钠他唑巴坦钠治疗小儿SSSS安全性高,能下调炎症因子水平及显著改善免疫功能,加速皮损愈合,缩短疗程。Objective To investigate the effect of external kangfuxin solution combined with piperacillin sodium tazobactam sodium on serum inflammatory factors and immune function of staphylococcal scalded skin syndrome(SSSS)in children.Methods A total of 90 hospitalized children with SSSS admitted to the Department of Pediatrics of People′s Hospital of Wugong County and the Department of Pediatrics of Xi′an International Medical Center Hospital in Shaanxi Province from January 2018 to December 2021 were selected as the study objects and divided into the treatment group and the control group by using the random number table method,with 45 cases in each group.Children in both groups were given cleaning of the skin erosion of wound fold and symptomatic supportive treatment.The control group was given piperacillin sodium tazobactam sodium 100 mg/(kg·d)which was added to 0.9%sodium chloride injection by intravenous drip,3 times a day for 7-14 days of treatment as a course of treatment.Based on giving piperacillin sodium tazobactam sodium treatment,the treatment group adopted disinfection cotton swabs dipped in kangfuxin solution external coating wound exposure,4 times a day for 7-14 days of treatment as a course of treatment.The clinical efficacy,inflammatory factors[including C-reactive protein(CRP),procalcitonin(PCT)and serum amyloid A(SAA)],immune function(including CD3^(+),CD4^(+),CD8^(+))and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the treatment group was higher than that in the control group,the fever remission,rash regression,negative change of Nikolsky′s sign and cure time were all shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the CRP,PCT,SAA,CD8^(+)levels in both groups decreased compared with before treatment,the CD3^(+),CD4^(+)levels in both groups increased compared with before treatment,and the CRP,PCT,SAA,CD8^(+)levels in the treatment group were lower than those in the co

关 键 词：康复新液 哌拉西林钠他唑巴坦钠 葡萄球菌烫伤样皮肤综合征 炎症因子 免疫功能 儿童 

分 类 号：R725[医药卫生—儿科]